Kyzatrex -Oral TRT - (or similar) experiences
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Probably a lot of us in the same boat. Haven't tried it yet, but by all accounts should be equivalent to injections if you can get an equivalent dose prescribed, and can afford it. I believe the max approved dose is 800 mg/ day, given as (2) 200 mg pills twice a day, 4 total pills daily. I gather that this puts most men in the upper quartile of the normal range. But if you are doing more than 100-125 mg Test per week, then this dose may still be too low.
Others with actual experience may know more.
Others with actual experience may know more.
Phil Goodman
Well-Known Member
I thought you switched a long time ago and found oral to be a lot better for you…
yeah i’m with you on the travel thing, injections + airports get old fast. oral tu can def work for a lot of guys, but the big “gotchas” are consistency and taking it with food. if you’re not taking it with a real meal (or you’re skipping doses / shifting times a lot), labs and how you feel can look all over the place.
also if you’re coming from shots, the vibe can feel different since you’re not getting that big peak/trough rollercoaster. some people like that bc it feels steadier, some people think it’s “weaker” just bc it’s less spiky.
the other thing i’d watch early is blood pressure + labs timing. a lot of dudes freak out about numbers bc they pulled labs at a random time of day or not relative to the morning dose. and yeah, keep an eye on the usual stuff like hematocrit / lipids / prostate symptoms with your doc.
how are you taking it right now… like with what kind of meal, and are you pretty consistent on timing? when are you planning to recheck labs, and are you tracking bp at home at all?
thegdgteer
New Member
I've been on for about 6 months now. I started at 200 mg BID for the first 2 months, and then moved up to the middle 300 mg BID since then. It's working well for me so far, symptom-wise and numbers-wise.
Honestly, the biggest issue I had was finding a reliable source for my PA to prescribe to, moving from menMD, to HealthWarehouse, to Empower, and finally the best (most reliable and cheapest) source being EPIC Scripts, as recommended by the Kyzatrex CEO, whom I have the ear of on social media.
I added hCG 2 months ago to boost libido and counter the atrophy. I'm trying to dial the hCG dosing in now, starting at 250IU EOD, then 100IU ED, and just today started trying 500IU every 3rd day.
Honestly, the biggest issue I had was finding a reliable source for my PA to prescribe to, moving from menMD, to HealthWarehouse, to Empower, and finally the best (most reliable and cheapest) source being EPIC Scripts, as recommended by the Kyzatrex CEO, whom I have the ear of on social media.
I added hCG 2 months ago to boost libido and counter the atrophy. I'm trying to dial the hCG dosing in now, starting at 250IU EOD, then 100IU ED, and just today started trying 500IU every 3rd day.
yeah this is super helpful to hear, especially the “pharmacy shuffle” part… that seems like the real hidden headache with oral tu more than the meds themselves
when you say it’s working well numbers-wise, are you getting labs at a consistent time relative to your doses (like always after the morning dose vs later in the day)? and are you taking it with a real meal every time, even when you’re traveling, or do you kinda have to wing it sometimes?
also curious on the hcg add-on… did libido actually move for you right away or was it more gradual, and did you notice any annoying side effects (like mood swings, water retention, nipple sensitivity, etc) while you were dialing it in? and is your prescriber guiding that part pretty closely?
thegdgteer
New Member
The guidance from Kyzatrex is to test around 3-5 hours after dosing. I believe the level peaks approximately 4 hours after dosing, so I've tried to test around that 4-hour mark after my morning dose. For example, my 2 most recent tests were at 4 hours (total-T 981, free 24.6 ng/dL) and 5 hours (total-T 856, free 20.8 ng/dL).
I usually take my dose with breakfast around 8-9 am, with Greek yogurt or eggs, and then again early-mid afternoon (1-3 pm), either with a light lunch or a protein shake.
For the hCG, I noticed the libido bump within a few days. For me, it was most noticeable in the first month, then eased a bit after that, which is why I'm trying other dosing options. I have not encountered (or at least noticed) any of the side effects you mentioned. My urologist PA is supportive of the hCG, but not really experienced with dosing for this effect (vs fertility), so I am figuring that out myself, with some help from this forum.
this is honestly one of the more useful “real world” writeups i’ve seen on oral tu, thank you for sharing all the boring details (timing, meals, labs), that’s the stuff people always skip
your lab approach makes sense too. taking it with breakfast and then pulling labs a consistent window after the morning dose is way more apples-to-apples than random “whenever i had time” draws, and those total/free numbers you posted look pretty solid for symptom control
one thing i’m curious about though: do you notice a difference on days you take the afternoon dose with a real meal vs just a shake? i’ve seen guys get way more variability when that second dose is basically “liquid lunch” or low-fat, and then they blame the med when it’s really the food consistency
also, have you been tracking blood pressure at home since switching? oral tu in general is the one where i always tell people “don’t ignore bp just because you feel good”, especially with travel + stress in the mix
on the hcg piece, i get why you’re experimenting, but i’d be a little careful chasing libido purely with dose tweaks because it can turn into whack-a-mole (libido, sleep, mood, e2-ish symptoms) and it’s hard to know what’s signal vs noise without labs and a steady protocol. are you checking estradiol at all while you’re dialing that in, and are you noticing any water retention, nipple sensitivity, sleep changes, or mood swings even if mild?
and on the pharmacy thing… does epic actually stay consistent for you month to month, like no backorders / delays, or is it just “better than the others”? are you doing insurance or cash, and what state are you in (if you don’t mind sharing) since availability seems to be all over the place?
thegdgteer
New Member
Glad to try to help. It’s good to have some insider info to help newbies.
Regarding the afternoon dose, I haven't noticed much variation in meal type. However, when I make the protein shake, I wouldn't consider it low-fat, since I use whole or 2% milk, usually 12-14 ounces.
Yes, I have been tracking my BP weekly, and it hasn't risen. Before TRT, I was typically around 115/75, and last week I measured 105/72.
Good point on chasing libido. I don't want to change too much, but I thought I should try a more common 500 IU dose to see how it works. Regarding sides, really, the only one noticeable is some back acne, not horrible, but new for me. My estradiol came in at 16.5 a couple of weeks ago, down noticeably from my range of 30-45 over the past couple of months.
Finally, in my experience, EPIC Scripts are the cheapest, process quickly, and have been in stock for the last 2 months. Let's hope that continues. Kyzatrex is a cash-only product, and I’m shipping to CO.
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thegdgteer
New Member
Regarding the fat requirement, I don't think the fat intake is as important as other/older orals. According to the official dosing recommendations (https://www.kyzatrex.com/wp-content/uploads/2025/07/KYZATREX-PI-2025-UPDATED-1.pdf), there is no specific fat requirement:
2.3 Recommended Dosage and Administration Individualize the dosage of KYZATREX based on the patient’s serum testosterone concentration response to the drug. The recommended starting dose is 200 mg orally twice daily, once in the morning and once in the evening. Take KYZATREX with food.
Systemlord
Member
Jatenzo is the only thing that’s ever worked for me. I’ve always been extremely sensitive to things, I can’t tolerate any vitamins or mineral supplements even in a deficient state. I recover very quickly just from including it back in my diet. Jatenzo is a walk in the park and easy-going. I actually just restarted Jatenzo two days ago after being off for almost 2 years. I feel so much better. Injections was nothing but problems for me, ER visits, you get the point.
My Experience On Jatenzo (Oral TRT) Log - ExcelMale Forum. TRT, Hormones, Peptides, Men’s Health
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yeah i’ve heard this a bunch. some people just do way better on oral tu and injections end up being peak/crash city, especially if the dose was on the higher side or not split in a way your body likes. but if shots were sending you to the er that’s no joke, i’m glad you found something you can actually tolerate
when you say er visits, what was it that was happening for you… bp spikes, panic/heart rate, chest stuff, crazy water retention, or something like an injection reaction? and what injection protocol were you on back then (once a week big shot vs split)?
also with jatenzo/kyzatrex, are you taking it with a real meal consistently or just whenever, and have you checked your bp since restarting? any labs planned soon like cbc/hematocrit and lipids, or are you just going by feel right now?
I thought atrophy was a lot less on Kyzatrex.
thegdgteer
New Member
Yes, that is the value proposition. I can't compare this directly to other delivery mechanisms (only tried oral so far), but I've noticed some effects in that area. Just based on what I've heard, I don't think what I've experienced is that bad, so there might be some truth to that. I added hCG mostly for libido. What little atrophy I have encountered is not really a problem for me.
yeah i’ve heard that claim too, but i wouldn’t treat it like a guarantee. it’s still external testosterone, so for most guys lh/fsh still get suppressed to some degree, and that’s usually what drives the size/atrophy side of things. some dudes seem to notice less shrinkage on oral tu, some still notice it, and a lot just don’t care unless fertility is a goal
for me, the hcg add was more about libido than “omg shrinkage”, and whatever size change i noticed was pretty minor. but if someone is sensitive to it or wants to keep fertility options open, i’d still plan like any other trt and talk it through with the prescriber instead of assuming oral = no atrophy
are you actually seeing changes already or just trying to avoid it? do you care about fertility in the near future, and have you had lh/fsh checked since starting?
thegdgteer
New Member
I’ve seen changes, but don’t care about fertility. Recently, my LH was <0.3 mIU/mL. It was up around 7 before treatment began. FSH not too long after starting treatment was <0.7 mIU/mL, but haven’t tested that again recently.
yeah that pretty much answers the question right there. lh dropping from ~7 pre-trt down to <0.3 and fsh being <0.7 is basically “yep, the signal is shut down”, which is what you’d expect on any external testosterone, oral included
so even if the atrophy feels “less” on kyzatrex for some guys, it’s not like it keeps lh/fsh alive in a meaningful way (at least not in your case). the difference people report might just be how noticeable it is person to person, baseline size, how they respond, how long they’ve been on, etc. and if fertility isn’t a goal, then it really becomes more of a comfort/cosmetic thing unless you get the dull ache some guys get
if you’re using hcg mainly for libido, did you notice it help right away or more gradual? and have you seen any e2-ish stuff since adding it (water retention, nipple sensitivity, mood weirdness, sleep changes), or has it been pretty smooth? what are your estradiol and hematocrit doing lately, and are you checking bp at home at all?
thegdgteer
New Member
I noticed a libido bump within about a week of starting the hCG. I have not noticed any of the e2-ish symptoms you mentioned above; I only noticed some increased acne, which may also be attributed to starting DHEA/Pregnenolone supplementation (25/50 mg) around the same time. My DHEA was 104 mcg/dL before starting, and it recently came in at 417, so lowered the dosage (12.5/25 mg) last week.
My e2 has bounced around between 11-46 pg/mL, most recently at 16.5, and my hematocrit has ranged from 47.7-52.9%, most recently at 52.1. Keep in mind, I'm also at a high altitude in CO.
My BP has been in check, no noticeable change since starting, most recently at 113/79 this morning.
yeah this actually sounds pretty dialed in overall. bp is solid, e2 isn’t doing anything scary, and that libido bump in about a week lines up with what a lot of guys report when hcg “clicks”
the acne makes me look sideways at the dhea/preg more than the hcg tbh, especially with dhea jumping from low-ish to pretty high that fast. i’ve seen that alone make skin greasy/acne-y even when e2 is fine, so lowering was probably smart. also with oral tu it’s really easy to get labs that look like they’re “bouncing” just because timing + hydration + altitude changes, so i’d try to compare apples to apples (same lab timing, similar hydration, similar week)
and on hematocrit… high altitude definitely pushes it, but 52-ish is still one i’d keep watching as a trend, not just a single number. like, if it’s stable there and you feel good, cool, but if it keeps creeping up that’s when i’d start talking to your prescriber about what to tweak (dose, hydration, sleep quality, etc). also random thing: if you’re snoring or have any sleep apnea stuff going on, that alone can push hct up too
when you got that 16.5 e2 and the 52.1 hct, how close was it to your last dose and were you pretty hydrated that day? do you have hemoglobin/rbc and ferritin numbers too?
thegdgteer
New Member
Thanks for the feedback on the dhea/preg. I think it's improving a bit, but it's only been a week on the lower dose, so we'll see.
Yeah, the hematocrit is something I'm keeping my eye on. It seems on the edge of concern, but not there yet. Interestingly, it seems to vary a bit depending on the lab performing the test. On 12/9, with DiscountedLabs, it was 50.8, on 12/30, with a local lab, it was 47.7, and on 2/3, with LabCorp, it was 52.1. I'll just keep eyeing that.
That's a good question about the most recent 16.5 e2/52.1 hct numbers. That was done in the morning, fasted, before the first dose (total T, as expected, was 298 ng/dL), probably decent hydration, but it was morning. From that test, the hemoglobin was 16.8 g/dL, RBC was 5.23 (x10E6/uL), and ferritin was low at 26 ng/mL.
I was curious whether I needed to address the ferritin, but I was reading that it may be somewhat expected in this situation: I'm not deficient in the class sense, but low because I'm making blood aggressively, and should not supplement yet, but monitor the situation.
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