Lab results seem way too high

ChristIsKing

New Member
Hi all,

I started TRT ~8 weeks ago. Taking 28mg test prop every day. I know that dose is on the higher side. I just got my labs back and the numbers seem extremely high. I wonder if they are right or something got messed up. I didn't take my shot that day until after I had the blood drawn. Should I just have the blood work done again or drop down to like 20mg/day then redo them? I'm feeling pretty good and no noticable sides.

SHBG was 47.8 range 16.5-55.9 a few months ago. I didn't have that tested this time.

1760977809943.webp

1760977837557.webp
 
Hi all,

I started TRT ~8 weeks ago. Taking 28mg test prop every day. I know that dose is on the higher side. I just got my labs back and the numbers seem extremely high. I wonder if they are right or something got messed up. I didn't take my shot that day until after I had the blood drawn. Should I just have the blood work done again or drop down to like 20mg/day then redo them? I'm feeling pretty good and no noticable sides.

SHBG was 47.8 range 16.5-55.9 a few months ago. I didn't have that tested this time.

View attachment 53573
View attachment 53574
Yes your numbers seem too high. How long after your injection did you have your Labs? Do you use HCG?

I actually think 20 mg would be too high and I would wait at least 12 weeks after changing your protocol to her labs.
 
Test prop peaks very high it's not surprising really
Not saying it's super accurate but on cycle planner test prop at 28mg a day peaks almost as high as 150mg of test e twice week
So 200mg of test prop a week peaks as much as 300mg of test e a week
 
Hi all,

I started TRT ~8 weeks ago. Taking 28mg test prop every day. I know that dose is on the higher side. I just got my labs back and the numbers seem extremely high. I wonder if they are right or something got messed up. I didn't take my shot that day until after I had the blood drawn. Should I just have the blood work done again or drop down to like 20mg/day then redo them? I'm feeling pretty good and no noticable sides.

SHBG was 47.8 range 16.5-55.9 a few months ago. I didn't have that tested this time.

View attachment 53573
View attachment 53574

Should have thought this through before jumping in head first here!

You are injecting a whopping daily dose of TP for TTh!

100 mg TP = 83 mg active T (minus ester)

100 mg TC = 70 mg active T (minus ester)

28 mg TP daily (196 mg/week) would be 162.68 mg active T (minus ester) week.

196 mg TP/week would be the equivalent of injecting roughly a whopping 232 mg TC/week which is overkill here!

Most men on TTh are injecting 100-200 mg T/week whether once weekly or split into more frequent injections as in twice-weekly (every 3.5 days), M/W/F, EOD or daily.

The majority of men can easily achieve a healthy/high trough FT injecting 100-150 mg T/week especially when split into more frequent injections.

Some men will achieve stellar levels injecting <100 mg T/week especially when split into more frequent injections.

Yes there will always be those outliers who will need the higher-end dose 200 mg T/week but its far from common as in rare!

Such dose would have the majority overmedicated on T!

You are injecting 196 mg TP/week split daily which again would be the equivalent of injecting a whopping 232 mg TC/week which is over the higher-end therapeutic dose a dose that the majority would never need to achieve a healthy let alone high trough FT.

TP is a different animal here as it is much shorter-acting due to the PK which will have a big impact on the daily peak--->trough level achieved as the peak can be 40-50% higher!

Standard starting dose for men injecting TC/TE is 100 mg T/week or 50 mg T split twice-weekly.

Some may even choose to start out lower.

Always start low and go slow we say!

There will always be time to increase your dose further if need be.

Much harder coming down than going up!

When using TP a sensible starting dose would be 12 mg daily (84 mg/week) which would be roughly the same as injecting 100 mg TC/week.

Yes you could bump it up a little higher but even then it is always best to start low and go slow as you want to see how your body reacts to testosterone and where said protocol (dose of T/injection frequency) will have your trough TT and more importantly FT, estradiol and critical blood markers RBCs, hemoglobin and hematocrit.

You left out estradiol and critical blood markers RBCs, hemoglobin and hematocrit?

Always need to know where your RBCs, hemoglobin and hematocrit sit!

Due to the PK you will reach steady-state much quicker than TC/TE.

Once you have achieved steady-state blood work will be done.

We always want to test at the true trough (lowest point) before your next injection which would be 24 hrs post-injection when using TP.

Yes you can always test your peak too!

Looking over your results even with a high-end SHBG highly doubtful you are hitting an absolutely ridiculous trough TT 2667 ng/dL and more importantly a ridiculous trough FT 77.4 ng/dL as if this was the case then your peak TT and more importantly FT would be insane as again there can be a 40-50%n difference in the peak--->trough!

Top it off that it would be rare not to be experiencing any sides running an absurdly high trough TT and more importantly FT.

It would be a given that most running too high a steady-state/trough FT would have elevated hematocrit!

You did use the most accurate assays for TT (LC/MS-MS) and FT (Equilibrium Dialysis) so chances are the results would be good to go but you can always retest to rule this out.

If such is the case then I would say your TP is dosed higher than you think if you are f**king with UGL!
 
Test prop peaks very high it's not surprising really
Not saying it's super accurate but on cycle planner test prop at 28mg a day peaks almost as high as 150mg of test e twice week
So 200mg of test prop a week peaks as much as 300mg of test e a week

Post #1

I started TRT ~8 weeks ago. Taking 28mg test prop every day. I know that dose is on the higher side. I just got my labs back and the numbers seem extremely high. I wonder if they are right or something got messed up. I didn't take my shot that day until after I had the blood drawn. Should I just have the blood work done again or drop down to like 20mg/day then redo them? I'm feeling pretty good and no noticable sides.


Post #3

Thanks, no HCG just test prop and low dose nandrolone (once a week at half of weekly test mg). Labs were 25 hours after last injection.



He never even tested at peak as his blood work was done 25 hrs post-dose!
 
Those numbers are most likely accurate. At one point I was taking 30mg prop a day and I measured at trough. Numbers were through the roof like yours. Its a different beast than cyp.
 
Last edited:
E2 was posted 109 LC/MS. It's really high but close to Nelson's ratio if the TT # is correct. I skipped today, going to drop down to 20mg TP & 20mg TC EOD starting tomorrow and took a tiny piece of a 1mg anastrozole I had on hand. Since I'm replacing some of the TP with TC, I'm guessing I'll need to wait at least a 6 more weeks before a blood test would show where my levels stabalized?

At least I'm not having any sides here except not being sore at all after working out when I used to be dead for 3 days lol. I don't mind being on the high to slightly supraphysiological range if I'm feeling good but not anywhere close to 2700 at the 'trough'.

I didn't post these since they were in range. PSA did jump from 1.5 pre to 4.73 which had me more concerned than the TT/FT numbers. I may have messed up that test by having sex within 24 hours of the labs. Forgot about that requirement. Only a small jump for RBC, hemoglobin & hematocrit.

1761077574230.webp
 
E2 was posted 109 LC/MS. It's really high but close to Nelson's ratio if the TT # is correct. I skipped today, going to drop down to 20mg TP & 20mg TC EOD starting tomorrow and took a tiny piece of a 1mg anastrozole I had on hand. Since I'm replacing some of the TP with TC, I'm guessing I'll need to wait at least a 6 more weeks before a blood test would show where my levels stabalized?

At least I'm not having any sides here except not being sore at all after working out when I used to be dead for 3 days lol. I don't mind being on the high to slightly supraphysiological range if I'm feeling good but not anywhere close to 2700 at the 'trough'.

I didn't post these since they were in range. PSA did jump from 1.5 pre to 4.73 which had me more concerned than the TT/FT numbers. I may have messed up that test by having sex within 24 hours of the labs. Forgot about that requirement. Only a small jump for RBC, hemoglobin & hematocrit.

View attachment 53584
Why would you make such an odd change to your protocol? Just lower your dose. Thats what your data is telling you to do. You could cut it in half and still be at the top of the range. I like prop because I know what to do much faster. Prop has less sides too which you experience personally. Only downside is the inconveince of injecting every day.
 
E2 was posted 109 LC/MS. It's really high but close to Nelson's ratio if the TT # is correct. I skipped today, going to drop down to 20mg TP & 20mg TC EOD starting tomorrow and took a tiny piece of a 1mg anastrozole I had on hand. Since I'm replacing some of the TP with TC, I'm guessing I'll need to wait at least a 6 more weeks before a blood test would show where my levels stabalized?

At least I'm not having any sides here except not being sore at all after working out when I used to be dead for 3 days lol. I don't mind being on the high to slightly supraphysiological range if I'm feeling good but not anywhere close to 2700 at the 'trough'.

I didn't post these since they were in range. PSA did jump from 1.5 pre to 4.73 which had me more concerned than the TT/FT numbers. I may have messed up that test by having sex within 24 hours of the labs. Forgot about that requirement. Only a small jump for RBC, hemoglobin & hematocrit.

View attachment 53584

Was missing that part of the screenshot (estradiol).

Again if the results are accurate and you are hitting those absurd levels 25 hrs post-injection I would say if its UGL gear than it could easily be overdosed which would make more sense here.

What brand of TP are you using?

Again if those results are accurate you can easily cut your weekly dose in half!

Would not waste your time injecting TP with TC EOD.

Far better off injecting TP daily due to the PK and to take advantage of the daily peak--->trough.

You can easily achieve a healthy/high trough FT cutting your weekly dose in half!

Would not get too caught up on everything looks good with your RBCs, hemoglobin and hematocrit just because they are still under the top-end of the reference range unless you know for a fact that your ferritin/iron is sitting in a healthy range.

Need to test your ferritin/iron to see where they sit.

Where did your RBCs, hemoglobin and hematocrit sit pre-TTh?

Have you ever donated blood?
 
E2 was posted 109 LC/MS. It's really high but close to Nelson's ratio if the TT # is correct. I skipped today, going to drop down to 20mg TP & 20mg TC EOD starting tomorrow and took a tiny piece of a 1mg anastrozole I had on hand. Since I'm replacing some of the TP with TC, I'm guessing I'll need to wait at least a 6 more weeks before a blood test would show where my levels stabalized?

At least I'm not having any sides here except not being sore at all after working out when I used to be dead for 3 days lol. I don't mind being on the high to slightly supraphysiological range if I'm feeling good but not anywhere close to 2700 at the 'trough'.

I didn't post these since they were in range. PSA did jump from 1.5 pre to 4.73 which had me more concerned than the TT/FT numbers. I may have messed up that test by having sex within 24 hours of the labs. Forgot about that requirement. Only a small jump for RBC, hemoglobin & hematocrit.

View attachment 53584


I don't mind being on the high to slightly supraphysiological range if I'm feeling good but not anywhere close to 2700 at the 'trough'.


No one would ever need to achieve those insane levels at peak let alone trough on T-therapy!

If your SHBG is still hovering around the high-end 48.7 nmol/L then you could easily get away with running a trough TT 1050-1240 ng/dL if your goal was to hit a high-end/high trough FT 20-25 ng/dL.

Still need to keep in mind if your are hitting a high-end/high trough FT 20-25 ng/dL on a daily TP protocol then your peak TT and more importantly FT would still be ridiculously high!

If you understand the PKs of the various esters TP vs TC or TE there is going to be a huge difference between one hitting a high-end/high trough FT 20-25 ng/dL injecting TP daily vs injecting TC/TE daily!

This is the downfall with daily TP as most are making the mistake of aiming for too high a trough FT which can backfire for many in the long-run as you are constantly hammering the s**t out of your dopamine and CNS!

Too many caught up on that more T is better mentality bulls**t!

Always need to be mindful of your injection frequency/where trough FT sits.

FT <5 ng/dL would be considerd low.

FT 5-9 ng/dL would be considered the grey zone where some men may experience symptoms of low-T.

FT 10-15 ng/dL would be healthy.

FT 20-25 ng/dL would be high-end/high!

The majority of men will do well with a trough FT 15-25 ng/dL depending on the injection frequency.

Need to keep in mind that there is a big difference between one running a high-end/high trough FT 20-25 ng/dL injecting daily vs twice-weekly vs once weekly.

Also going to be a big difference in peak--->trough on said protocol!

Again If you understand the PKs of the various esters TP vs TC or TE there is going to be a huge difference between one hitting a high-end/high trough FT 20-25 ng/dL injecting TP daily vs injecting TC/TE daily!

Many tend to overlook this and gun for a high-end/high trough FT only to end up struggling with sides especially in the long run.

Just to put this in perspective most healthy young males would be hitting a cFTV 13-15 ng/dL or 10-12 ng/dL tested using the most accurate assay the gold standard Equilibrium Dialysis and this is a short-lived daily peak to boot!

Even if you take those natty outliers in the 95th percentile hitting a high FT 25 ng/dL again this is a short-lived daily peak to boot!

You have guys on T hitting a trough FT 25-30+ ng/dL injecting daily with FT elevated 24/7, EOD as in every 2 days (48 hrs post-injection), twice-weekly as in every 3.5 days (84 hrs post-injection), once weekly as in 7 days post-injection.

You get the point here.




*Serum samples were analyzed from healthy men participating in the SIBLOS/SIBEX and EMAS studies, both population-based cohort studies

* mFT levels were measured in 867 men using ED LC-MS/MS as previously reported (1). Subsequently, 95% reference ranges were determined using the non-parametric method


We present 95% mFT age-stratified reference ranges. These reference ranges show an expected, decreasing trend of mFT with aging. Lower limits and median mFT decrease at a remarkably stable rate of, on average, 12% per decade up into the 6th decade of life. However, in the upper limit, a marked decrease of 25% occurs after 39 years, followed by smaller decreases of 6% per decade in older age categories.



Age category (years)

Median mFT (ng/dl)

95% mFT reference range (ng/dl)

18-29 (n=140)
30-39 (n=252)

12.0
9.8

6.7-25.3
4.9-18.5

40-49 (n=207)

8.1

4.3.14.2

50-59 (n=146)

7.1

3.8-12.8

60-69 (n=126)

6.4

3.4-11.7

70-79 (n=125)

5.6

2.7-8.7


Conclusion

We have determined mFT reference ranges in healthy men aged 25 to 69. These reference ranges are a first step to improving the framework for further development and integration of free testosterone measurements and calculations in clinical practice.





 

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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