Controversies with Testosterone Therapy - Management of Erythrocytosis and Elevated Estradiol

[madman]

* No universally accepted cutoff: 30, 40, or 50 pg/mL?




Controversies with Estradiol

 

[madman]

Clinical Approach to Elevated Estradiol & TRT

 

[madman]

Future Directions

 

[madman]

Conclusions

 

[madman]

Thread 'Estrogen-It's what makes a real man'

Sep 24, 2022

Study: Low estrogen can cause problems for men

Study: Low estrogen can cause problems for men (2013)​

Dr. Joel Finkelstein, an endocrinologist at Harvard Medical School and the lead author of a new study, talks about the effects of declining estrogen in men.

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men (2013)​

Joel S. Finkelstein, M.D., Hang Lee, Ph.D., Sherri-Ann M. Burnett-Bowie, M.D., M.P.H., J. Carl Pallais, M.D., M.P.H., Elaine W. Yu, M.D., Lawrence F. Borges, M.D., Brent F. Jones, M.D., Christopher V...

• madman
• estrogen; testosterone; hypogonadism
• Replies: 24
• Forum: Testosterone and Men's Health Articles

• 

 

[madman]

Thread 'Testosterone Therapy and Erythrocytosis - the most common dose-limiting effect of testosterone therapy'

Apr 21, 2024

Testosterone Therapy and Erythrocytosis • The Blood Project

Introduction Androgens play a crucial role in the development and maintenance of: Male reproductive and sexual functions Body composition Erythropoiesis

www.thebloodproject.com

Introduction

• Androgens play a crucial role in the development and maintenance of:
  
  • Male reproductive and sexual functions
  • Body composition
  • Erythropoiesis
  • Muscle and bone health
  • Cognitive function
• Testosterone falls progressively with age and a significant percentage of men over the age of 60 years have serum testosterone levels that are below the lower limits of young...

• madman
• hypogonadism; testosterone; hematocrit; cvd
• Replies: 17
• Forum: Testosterone Side Effect Management

• 

 

[Nelson Vergel]

Great graphics. Unfortunately, not a great job on showing more data on estradiol benefits. At least he mentions some of the risks of overtreating estradiol. Also, never addressed what “ treat based on symptoms” means. Most symptoms blamed on high estradiol have nothing to do with E2.

 

[Seagal]

Great graphics. Unfortunately, not a great job on showing more data on estradiol benefits. At least he mentions some of the risks of overtreating estradiol. Also, never addressed what “ treat based on symptoms” means. Most symptoms blamed on high estradiol have nothing to do with E2.

It's about Erythrocytosis. Maybe treat based on symptoms vs treat based on numbers. I recall an earlier study which linked E2 to Erythrocytosis, and it employed AI to manage it when E2 was high on modest TT levels.

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[Seagal]

Example of some of the data looking at the rates of erythrocytosis
View attachment 53312

Why the difference between TU and TE/TC? What dose and injection intervall?
When topical is mentioned it probably means Androgel. Not the same as twice daily high percentage Testo cream. Etcetera

You provided a much clearer correlation, i.e. accumulated free T.

Oral TU is outstanding. Why? That's intriguing.

 

[madman]

Great graphics. Unfortunately, not a great job on showing more data on estradiol benefits. At least he mentions some of the risks of overtreating estradiol. Also, never addressed what “ treat based on symptoms” means. Most symptoms blamed on high estradiol have nothing to do with E2.

You would need to listen to the full presentation which includes a Q&A at the end to catch the gist here.

I will be post the link after I am done posting some of the other presentations.

Unfortunately he did not spend enough time on the benefits (bone health, libido & erectile function, metabolic regulation) as the presenters were only given 20-30 minutes and he was the last one on the panel so he only had 15 minutes!

Dr Khera was the moderator.

Dr. Lipshultz was there too!

 

[Mastodont]

Why the difference between TU and TE/TC? What dose and injection intervall?
When topical is mentioned it probably means Androgel. Not the same as twice daily high percentage Testo cream. Etcetera

You provided a much clearer correlation, i.e. accumulated free T.

Oral TU is outstanding. Why? That's intriguing.

I can tell you why, that data is based on manufacturers data, on frequency of 10-12 weeks for the 1000mg injection, so people are spending most of that time in physiological levels and even low levels for the last weeks.

 

[Seagal]

I can tell you why, that data is based on manufacturers data, on frequency of 10-12 weeks for the 1000mg injection, so people are spending most of that time in physiological levels and even low levels for the last weeks.

The nebido protocol.

For oral TU the data is then probably based on once daily protocol, resulting in less accumulated fT over the day and enough time to clear E2.