Controversies with Testosterone Therapy - Management of Erythrocytosis and Elevated Estradiol

[madman]

* No universally accepted cutoff: 30, 40, or 50 pg/mL?




Controversies with Estradiol

 

[madman]

Clinical Approach to Elevated Estradiol & TRT

 

[madman]

Future Directions

 

[madman]

Conclusions

 

[madman]

Thread 'Estrogen-It's what makes a real man'

Sep 24, 2022

Study: Low estrogen can cause problems for men

Study: Low estrogen can cause problems for men (2013)​

Dr. Joel Finkelstein, an endocrinologist at Harvard Medical School and the lead author of a new study, talks about the effects of declining estrogen in men.

Gonadal Steroids and Body Composition, Strength, and Sexual Function in Men (2013)​

Joel S. Finkelstein, M.D., Hang Lee, Ph.D., Sherri-Ann M. Burnett-Bowie, M.D., M.P.H., J. Carl Pallais, M.D., M.P.H., Elaine W. Yu, M.D., Lawrence F. Borges, M.D., Brent F. Jones, M.D., Christopher V...

• madman
• estrogen; testosterone; hypogonadism
• Replies: 24
• Forum: Testosterone and Men's Health Articles

• 

 

[madman]

Thread 'Testosterone Therapy and Erythrocytosis - the most common dose-limiting effect of testosterone therapy'

Apr 21, 2024

Testosterone Therapy and Erythrocytosis • The Blood Project

Introduction Androgens play a crucial role in the development and maintenance of: Male reproductive and sexual functions Body composition Erythropoiesis

www.thebloodproject.com

Introduction

• Androgens play a crucial role in the development and maintenance of:
  
  • Male reproductive and sexual functions
  • Body composition
  • Erythropoiesis
  • Muscle and bone health
  • Cognitive function
• Testosterone falls progressively with age and a significant percentage of men over the age of 60 years have serum testosterone levels that are below the lower limits of young...

• madman
• hypogonadism; testosterone; hematocrit; cvd
• Replies: 17
• Forum: Testosterone Side Effect Management

• 

 

[Nelson Vergel]

Great graphics. Unfortunately, not a great job on showing more data on estradiol benefits. At least he mentions some of the risks of overtreating estradiol. Also, never addressed what “ treat based on symptoms” means. Most symptoms blamed on high estradiol have nothing to do with E2.

 

[Seagal]

Great graphics. Unfortunately, not a great job on showing more data on estradiol benefits. At least he mentions some of the risks of overtreating estradiol. Also, never addressed what “ treat based on symptoms” means. Most symptoms blamed on high estradiol have nothing to do with E2.

It's about Erythrocytosis. Maybe treat based on symptoms vs treat based on numbers. I recall an earlier study which linked E2 to Erythrocytosis, and it employed AI to manage it when E2 was high on modest TT levels.

​

 

[Seagal]

Example of some of the data looking at the rates of erythrocytosis
View attachment 53312

Why the difference between TU and TE/TC? What dose and injection intervall?
When topical is mentioned it probably means Androgel. Not the same as twice daily high percentage Testo cream. Etcetera

You provided a much clearer correlation, i.e. accumulated free T.

Oral TU is outstanding. Why? That's intriguing.

 

[madman]

Great graphics. Unfortunately, not a great job on showing more data on estradiol benefits. At least he mentions some of the risks of overtreating estradiol. Also, never addressed what “ treat based on symptoms” means. Most symptoms blamed on high estradiol have nothing to do with E2.

You would need to listen to the full presentation which includes a Q&A at the end to catch the gist here.

I will be post the link after I am done posting some of the other presentations.

Unfortunately he did not spend enough time on the benefits (bone health, libido & erectile function, metabolic regulation) as the presenters were only given 20-30 minutes.

Dr Khera was the moderator.

Dr. Lipschultz was there too!