Lumos Hopes Its Oral Alternative to HGH Will Fuel Its Growth

madman

Super Moderator

Growth hormone deficiency is a rare condition that is the result of inadequate secretion of growth hormone from the pituitary gland. Though recombinant human growth hormone has long been used to treat people with pediatric growth hormone deficiency, it requires either daily or weekly injections and when injections are missed, results can be sub-optimal. Lumos Pharma is developing a once-daily oral therapy that works by promoting secretion of growth hormone. We spoke to Rick Hawkins, chairman and CEO of Lumos Pharma, about the company’s experimental therapy, how it works, and why it may be an attractive alternative to existing approaches.
 







 
Patent filed for new formulation

*USPTO response likely later this year

*Expect orange book listing with IP protection through late 2042



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Growth hormone deficiency is a rare condition that is the result of inadequate secretion of growth hormone from the pituitary gland. Though recombinant human growth hormone has long been used to treat people with pediatric growth hormone deficiency, it requires either daily or weekly injections and when injections are missed, results can be sub-optimal. Lumos Pharma is developing a once-daily oral therapy that works by promoting secretion of growth hormone. We spoke to Rick Hawkins, chairman and CEO of Lumos Pharma, about the company’s experimental therapy, how it works, and why it may be an attractive alternative to existing approaches.
They did not develop it. They just were smart enough to pick up an abandoned Merck drug (ibutamoren) for a pediatric growth hormone treatment. It’s already approved for GH challenge test in pediatrics.
 
They did not develop it. They just were smart enough to pick up an abandoned Merck drug (ibutamoren) for a pediatric growth hormone treatment. It’s already approved for GH challenge test in pediatrics.
Yes they have made it clear that Merck developed it.

13:58-16:50
 

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Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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