Revolutionizing Pediatric Growth Hormone Deficiency Treatment

madman

Super Moderator

Rick Hawkins, CEO and chairman of Lumos Pharma, discusses the company’s late-stage development of a small molecule for the treatment of pediatric growth hormone deficiency (PGHD). This innovative oral mini tablet aims to revolutionize the current standard of care, which involves daily injections for several years. The potential impact on the $5 billion global growth hormone market could be significant if the trial results are positive.


Highlights:


  • Rick Hawkins, CEO and chairman of Lumos Pharma, discusses the company’s late-stage development of a small molecule for PGHD.
  • The global phase 2B trial results for the oral mini tablet in the treatment of PGHD are forthcoming.
  • The current standard of care for PGHD involves daily injections for several years.
  • The growth hormone market is valued at approximately $5 billion globally.
  • Injectable growth hormone is the current standard treatment for PGHD and other growth hormone disorders.
  • Lumos Pharma’s innovation aims to provide a daily oral mini tablet as an alternative to daily injections for PGHD patients.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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