Kisspeptin-10

Anyone using K-10 as a alternative to HCG? I removed Hcg from my TRT protocol due to a recent battle with cancer and my balls are feeling (and looking) pretty miserable. I’m hoping K-10 can at least restore some size. I’m planning on using 0.10ml daily (Taylor Made Compounding Pharmacy protocol) although I’m sourcing the peptide elsewhere.

Thoughts?
 
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It might help, but there's little information about this application. Because kisspeptin cannot be prescribed there's not going to be widespread use anytime soon. You can also go one hormone downstream and use gonadorelin. Royal Medical Center has offered some data showing that LH and FSH pulses are produced at larger doses. Their protocol involves twice-weekly dosing, which seems kind of infrequent for preserving testicular function. It would be useful to get feedback on results from guys on this protocol.
 
Hi. Can I ask why you are taking it ?
I can no longer use HCG. I’m 2 weeks into K-10…so far nothing spectacular. No improvement in size. The only noticeable change has been the dull ache has gone away and my balls have dropped a bit. They were riding “high & tight” since I stopped HCG (approx 8 months). Which was quite uncomfortable at times.
 
I can no longer use HCG. I’m 2 weeks into K-10…so far nothing spectacular. No improvement in size. The only noticeable change has been the dull ache has gone away and my balls have dropped a bit. They were riding “high & tight” since I stopped HCG (approx 8 months). Which was quite uncomfortable at times.
Any update on this? How are you feeling?
 
I feel relatively great. I’m currently using the K-10 at 150mcg (increased from 100mcg) M-W-F and while my balls no longer stay in the high and tight position, K-10 has done nothing to restore size. Libido has increased substantially but I cannot say for certain if it’s due to K-10 because my recent labs had my DHT at 80 / SHBG 19 / Estrogen 50 / Total T 675 / Free T 138 / DHEA 230
 

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This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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