How does 125IU of HCG ED affect hormones production while on TRT?

just my anecdotal after a week on 125IU daily, my orgasm seems improved, libido, erection and penis sensitivity to some degree as well, no gain in testicle size, I think my mood improved as well. I was also on a trip for a few days though, I will see what happens this week that I'm back home with the usual routine
 
just my anecdotal after a week on 125IU daily, my orgasm seems improved, libido, erection and penis sensitivity to some degree as well, no gain in testicle size, I think my mood improved as well. I was also on a trip for a few days though, I will see what happens this week that I'm back home with the usual routine

Thanks for the follow up report.

FWIW as an anecdote of N=1, My current 160mg EOD definitely does prevent some testicular atrophy, but does not provoke E2 SEs. At 180iu EOD, I get E2 sides.
 
Thanks for the follow up report.

FWIW as an anecdote of N=1, My current 160mg EOD definitely does prevent some testicular atrophy, but does not provoke E2 SEs. At 180iu EOD, I get E2 sides.

thanks for your feedback, so Dr John Crisler was not entirely wrong on small HCG daily dosing,
 
Unfortunately HCG never did anything for my upstream or downstream hormones. I've run up to 500iu EOD alongside trt and also as a monotherapy, yet my cortisol, progesterone, 17-OH Prog and DHEA were always below range; coming off trt restores all four to normal. It did, however, send my prolactin 4x above top of the range, which completely destroyed all sensitivity downstairs.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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