Estrogen Dominance & Progesterone

Diablo666

Member
Hi,

I have the symptoms of high E2 (bloating, mild gyno, ED, low libido, irritability, etc). I have been using Anatrozole but it is a fucking hit or miss, the times I ever felt good tye most it last are from a few days to a few hours. I have also tried to try with lower doses and no AI, but no sex drive at all, even if other symptoms improve.

I checked my progesterone is almost zero, well under the range. Has anyone corrected their E2 symptoms through supplementing either pregnenolone or progesterone instead of recurring to AI?

I am thinking of give it a try but would love to hear if anyone has already tried that.
 
Hi,

I have the symptoms of high E2 (bloating, mild gyno, ED, low libido, irritability, etc). I have been using Anatrozole but it is a fucking hit or miss, the times I ever felt good tye most it last are from a few days to a few hours. I have also tried to try with lower doses and no AI, but no sex drive at all, even if other symptoms improve.

I checked my progesterone is almost zero, well under the range. Has anyone corrected their E2 symptoms through supplementing either pregnenolone or progesterone instead of recurring to AI?

I am thinking of give it a try but would love to hear if anyone has already tried that.
In men shouldn't the progesterone be almost zero?
 
Hi,

I have the symptoms of high E2 (bloating, mild gyno, ED, low libido, irritability, etc). I have been using Anatrozole but it is a fucking hit or miss, the times I ever felt good tye most it last are from a few days to a few hours. I have also tried to try with lower doses and no AI, but no sex drive at all, even if other symptoms improve.

I checked my progesterone is almost zero, well under the range. Has anyone corrected their E2 symptoms through supplementing either pregnenolone or progesterone instead of recurring to AI?

I am thinking of give it a try but would love to hear if anyone has already tried that.
What werre your E2 levels? Mine is in top 20% of range... I had same symptoms and still do, but Arimidex was poison to me... maybe you should try extra zinc... maybe Damiana... Quecertain... 7-Methoxyflavone... you might get results without the side effects...
 
What werre your E2 levels? Mine is in top 20% of range... I had same symptoms and still do, but Arimidex was poison to me... maybe you should try extra zinc... maybe Damiana... Quecertain... 7-Methoxyflavone... you might get results without the side effects...

Via a cooperative Primary Care MD and my Urologist, we worked together for 18 months, and found for me the proper balance of Testosterone Cypionate injections and Anastrozole tabs.
I'm 77, with serious but non-life-threatening neurological diseases. A weekly T-shot and a weekly tiny 1/4 mg Anastrozole tab yields a T-level around 700 ng/dL, and E2 < 20 ng/dL, and my PSA is always checked, and is in the 3.5 ng/mL range.

My Pain Doctor feels strongly that my pain meds are much more effective when my T-level is in the 700 range. Five years ago, T was 80 ng/dL, E2 was 200 ! + PSA was 14 !

All better now.
 
Hi,

I have the symptoms of high E2 (bloating, mild gyno, ED, low libido, irritability, etc). I have been using Anatrozole but it is a fucking hit or miss, the times I ever felt good tye most it last are from a few days to a few hours. I have also tried to try with lower doses and no AI, but no sex drive at all, even if other symptoms improve.

I checked my progesterone is almost zero, well under the range. Has anyone corrected their E2 symptoms through supplementing either pregnenolone or progesterone instead of recurring to AI?

I am thinking of give it a try but would love to hear if anyone has already tried that.
I have used oral progesterone in the past with my old clinic. I can’t answer all your questions but I’ll share my experience with it. Pre TRT my prog was top of the reference range now it’s practically zero. Which is why I was give prog in the first place as well at the time my DHT was beyond measurably high. I’d say overall I regret taking it as I believed it caused me more feminization sides than E2 ever did. My E2 has been all over the map from 0-70 pg/ml with no perceived feminizing sides. It was only when I was on a 50mg oral prog that I developed clinical gynecomastia and fat on my hips that I never had before. The only other factor that change was my HCG dose went from 100 iu to 300 iu daily with androgel. But again E2 never went past 45 pg/ml DHT 250+ ng/dl . The benefits I did have with prog was the best sleep of my life with extremely vivid dreams. There was a diuretic effect as well. Overall tough to personal recommend as it seems information on prog in men is limited.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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