Any thoughts?

wesley_tinker

New Member
Okay so I've been on TRT for 5 weeks now. 200 mg week and was prescribed 1mg of arimidex daily. After about 2 weeks on T I started feeling better, sleep was good, anxiety pretty much gone, libido showing signs of coming back and I could feel my insulin resistance normalizing. Then about a week and a half ago I started feeling horrible again. I read arimidex at 1mg daily is a killer of all things good about TRT. I stopped taking it, last dose last Sunday. The pharmacist said it takes 8 days to stop working. I did labs a few days ago and my estradiol came back as 20, which is bottom of scale. It wasn't a sensitive estradiol test. The dr seemed to think maybe coming off arimidex the 10 days earlier probably brought my number up but me feeling like crap may take a bit longer. All I know is I'm dog tired with no libido and slightly anxious. Does anyone have any thoughts or words of encouragement?
 
Why did your doctor prescribe such high dose of anastrozole?

Your estradiol is probably a lot lower than that if measured by ultrasensitive test. You were taking an excessive anastrozole dose. Anastrozole binds very tightly to the estrogen receptors.

We have had people like you complain about the same symptoms after tanking their estradiol. It takes a few weeks to have estradiol bounce back again.

Hang in there. Let us know how things go.
 
Thanks! I'm not real happy with the doc rightnow. The effects of low estradiol is horrible! A female friend of mine said now I know what it's like to go through menopause ha. Not fun but I'm still learning! Hopefully I'll get back on track soon.
 
Besides being irresponsible? There was never an initial estradiol test performed.

The older I get and the more I pay attention to my health and things I see/hear many doctors do, I have very little confidence in doctors. I acknowledge they are necessary, but far too often things they do are just beyond crazy.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
1
Guests online
260
Total visitors
261

Latest posts

Back
Top