E2 in single digits again

Vitamin_C

Member
My E2 is back into single digits again but this time as opposed to last time I have no low E2 symptoms, no ED, no joint pain, no overt anxiety, I was actually really surprised to see my E2 was low this time around, weird how the body works.
 
My E2 is back into single digits again but this time as opposed to last time I have no low E2 symptoms, no ED, no joint pain, no overt anxiety, I was actually really surprised to see my E2 was low this time around, weird how the body works.

Helps when you expand on an existing thread and/or details so we know what's up w you.
 
About a year ago I crashed my E2 to single digits and had anxiety, a little joint pain, and ED, night sweats . This time around I was just taking my standard .25 of Adex twice weekly and it was back in single digits but I was symptom free this time, had no idea it was even low . No joint pain, great wood and libido, no night sweats, minimal to no anxiety .
 
Even though you're not having any low symptoms. I wouldn't let my estradiol levels run that low, too many health issues are caused by low levels.
 
Oh yeah I’m def dropping the AI for a bit, I just think it’s interesting I have no low E2 symptoms this time around .
That is interesting. You would think that having an E2 in the single digits would certainly cause symptoms considering you've had low E2 symptoms in the past. Just goes to show that there is probably more we don't know than do know about TRT.
 
That is interesting. You would think that having an E2 in the single digits would certainly cause symptoms considering you've had low E2 symptoms in the past. Just goes to show that there is probably more we don't know than do know about TRT.

Exactly, I felt zero low E2 symptoms , unless there was a lab error my E2 is 6 on the SonoraQuest labs ultra sensitive assay. Waking up with wood, libido very high, strong erections , no mood problems, no brain fog , minimal joint pain, hair soft and skin not dry.
 
Before I started trt I did have single-digit estradiol levels. Though I never had any symptoms from them. Plus my whole time on trt I've never had any symptoms from estrogen.
 
Oh yeah I’m def dropping the AI for a bit, I just think it’s interesting I have no low E2 symptoms this time around .

To me this is a big RED flag the accuracy of your blood test should be questioned.
LabCorp has errored twice on me in the last 18 months. One caused me to crash my feritin when I acted on the bogus HCT.
 
To me this is a big RED flag the accuracy of your blood test should be questioned.
LabCorp has errored twice on me in the last 18 months. One caused me to crash my feritin when I acted on the bogus HCT.

Totally agree...when you get one test that is out of the ordinary unfortunately the prudent advice here is to discount the result.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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