Significantly lower serum melatonin levels were observed in CLL patients compared to healthy subjects. Patient had misalignment of the internal clock with the external light–dark cycle. The circadian rhythm of melatonin was disrupted, and the levels of melatonin were low compared to healthy subjects.
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National Center for Biotechnology Information › pmc
I scanned the paper. It is of interest, especially as a downregulator of BCL-2, which is the target of the anti cancer drug that I am taking that finally subdued it.
"The safety data on melatonin is astounding. So far no one has been able to find a toxic dose! Many of the leading researchers on melatonin in the world take more than 100 mg every day just to prevent cancer. I routinely start all my cancer patients on a minimum of 60 mg per day and use up to...www.excelmale.com
I must comment on the "immune booster" terminology as it is misleading and dangerous for active CLL cancers since the CLL cells ARE IMMUNE CELLS! They do not function properly as such, but that which boosts "the immune system" can also cause proliferation of CLL cells.
However, the study abstract that the article referred to is intriguing and says something different: Melatonin induces apoptosis through a caspase‐dependent but reactive oxygen species‐independent mechanism in human leukemia Molt‐3 cells | Semantic Scholar
Also, this study refers to Molt-3 cells which are malignant T-cells, not B-cells.