Low progesterone? Frustrated. Thinking of pulling the plug on TRT for good.

antelopers

Active Member
I had labs done recently. My protocol was 70mg twice per week, no HCG or AI. Only supplements were vitamin C and D and fish oil. I ran progesterone for the first time in years. All of my labs were relatively good, but my progesterone was completely undetectable, <0.1.

My pregnenolone was 31 (range says <150) I know the test is unreliable but checked it anyway

Dhea-s was 311 without supplementation so I assumed adrenal function was good.

From what i see from select sources, progesterone levels are absolutely essential for things like erections, libido, thyroid function, etc. Some sources say progesterone isn't important in males and other sources say it's crucial.

I have extremely low libido and poor erections.

I'm not even sure if I have a direct question but I'm seeking some input because I've just about had it.

Can HCG raise progesterone levels enough? It does seem to give me a slight libido but is by no means a complete cure and has its own side effects.

I have tried pregnenolone in the past for different purposes but if anything it made sexual function worse. I did not test progesterone at that time.

I just don't want to end up micromanaging 10 medications for my whole life either. Injecting T/HCG a couple of times a week is one thing, but daily injections and drugs for progesterone, prolactin, ED medications, it seems every time I talk to defy they just want to give me new medications.

I'm not sure what else to do at this point. I've tried creams, frequent injections, infrequent injections, propionate, aromatase inhibitors, Cialis, etc.

A lot of thing sucked for me before TRT but at least erections and libido worked better than now.

After nearly 8 years spinning my wheels I'm frustrated enough to give up on trt entirely if I don't figure out a solution soon. I'm 33 so I assume I have at least a chance at recovery even if I've been on forever.

All labs from my test:

Total T: 980
SHBG: 35
E2 Sensitive: 34

Pregnenolone: 31
DHEA-S: 311
Prolactin: 12.9
Progesterone: <0.1

TSH: 1.1
Free T4: 1.06
Free T3: 3.2
Reverse T3: 11.7
 
Last edited:

Vince

Super Moderator
If you're really thinking about stopping trt, what stopping you from trying HCG? Personally I'm a big fan of HCG. I've been injected now for 5 and 1/2 years, I wouldn't think of doing trt without it.
 

antelopers

Active Member
If you're really thinking about stopping trt, what stopping you from trying HCG? Personally I'm a big fan of HCG. I've been injected now for 5 and 1/2 years, I wouldn't think of doing trt without it.
I've tried it many times. I get a slight libido boost for a week or two followed by high estrogen, side effects like gynecomastia, etc. I've never been able to restore that "drive" to actually want sex, and if I'll be able to perform is a crapshoot.
 
Correct me if I am wrong, but as opposed to most hormones, progesterone is easily absorbed in pill form. My wife is on HRT, and that is the only one she takes orally. I realize you don't want to manage a bunch of prescriptions, but that one would be pretty easy. Assuming your doctor gets the dosing correct etc.
 

Cataceous

Well-Known Member
I wish I could just tell you the protocol that's going to make things work. But it's never that easy, is it? Instead all I can tell you is that what's really improved my quality of life is trying to mimic normal levels of hormones as much as possible, including neglected ones such as GnRH. It has resulted in a ridiculously complex protocol, but results are good enough to make it worthwhile. Part of the complexity is because I have to replace quite a few hormones; e.g. I have some indications from hCG use that my endogenous testosterone production will be inadequate regardless. Whereas you, at 25 years younger, have greater potential for normal natural production of most things.

So anyway, if I were 33 and feeling adventurous I would be interested in trying kisspeptin monotherapy. It might still be pretty tedious to test, requiring multiple small daily injections. But if the hormonal problems originated upstream of there then kisspeptin should make everything downstream act normally: GnRH, LH, FSH, T, E2. If the results were good then it would be worth exploring the use of an infusion pump. If kisspeptin didn't work out then I'd go on down to GnRH and do the same thing. I know, you're thinking this still all sounds too complicated. But you're way too young to spend the rest of your life feeling crappy.
 

antelopers

Active Member
I wish I could just tell you the protocol that's going to make things work. But it's never that easy, is it? Instead all I can tell you is that what's really improved my quality of life is trying to mimic normal levels of hormones as much as possible, including neglected ones such as GnRH. It has resulted in a ridiculously complex protocol, but results are good enough to make it worthwhile. Part of the complexity is because I have to replace quite a few hormones; e.g. I have some indications from hCG use that my endogenous testosterone production will be inadequate regardless. Whereas you, at 25 years younger, have greater potential for normal natural production of most things.

So anyway, if I were 33 and feeling adventurous I would be interested in trying kisspeptin monotherapy. It might still be pretty tedious to test, requiring multiple small daily injections. But if the hormonal problems originated upstream of there then kisspeptin should make everything downstream act normally: GnRH, LH, FSH, T, E2. If the results were good then it would be worth exploring the use of an infusion pump. If kisspeptin didn't work out then I'd go on down to GnRH and do the same thing. I know, you're thinking this still all sounds too complicated. But you're way too young to spend the rest of your life feeling crappy.
Appreciate that. I haven't seen anything about people being successful with kisspeptin, do you know of anyone it works for? I also thought it was recently banned from production in compounding pharmacies.

I'm thinking about making an appointment with defy and explaining all of this in excruciating detail and asking them to treat me like I'm a brand new patient, or if they would advise me coming off completely, or using something like you recommended.

Like you said, I'm way, way, way too young to be feeling like this, TRT or not. For a lot of guys, every protocol works, some better than others. For those of us where nothing works, there has to be something else we're missing. Maybe it's the gnrh like you described.
 

Cataceous

Well-Known Member
My understanding is that compounding pharmacies can no longer offer most peptides, and it's nothing against kisspeptin per se. I don't know anyone using kisspeptin yet, though there's a fair bit of promising research on it. It's somewhat telling that Peptide Sciences recently started offering it. This suggests that demand is increasing.

I expect GnRH therapy is a little too cutting edge for Defy, but I'd be happy to be wrong about that. At least it is a proven treatment; it's just that its complexity limits its popularity. While I don't want to create unrealistic expectations, this is the best I've felt overall since well before starting TRT. It seems to have been accomplished mainly by replacing hCG with GnRH and enclomiphene. I'd also switched to an enanthate/propionate blend injected daily to create more realistic serum testosterone levels. It's still possible that daily GnRH added to a conventional TRT/hCG protocol would provide benefits. We really need some research to explore this, as that would be more practical than what's needed to stimulate endogenous production of LH and FSH.
 

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