Kisspeptin Dosage

[FunkOdyssey]

Kisspeptin is looking increasingly promising for improving libido and sexual function. Check out this new study:

Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial

Does kisspeptin administration modulate sexual brain processing in men with low sexual desire due to hypoactive sexual desire disorder (HSDD)?In this randomized clinical trial of 32 men with HSDD, kisspeptin administration significantly modulated brain ...

www.ncbi.nlm.nih.gov

Can anyone (@readalot ?) help me figure out what 1 nmol/kg of kisspeptin translates to in micrograms? That is the dose per hour they gave these men, for 1 hour and 15 minutes. I assume a subcutaneous shot of the same dosage would be a good starting point if I wanted to experiment with it.

 

[tareload]

Kisspeptin is looking increasingly promising for improving libido and sexual function. Check out this new study:

Effects of Kisspeptin on Sexual Brain Processing and Penile Tumescence in Men With Hypoactive Sexual Desire Disorder: A Randomized Clinical Trial

Does kisspeptin administration modulate sexual brain processing in men with low sexual desire due to hypoactive sexual desire disorder (HSDD)?In this randomized clinical trial of 32 men with HSDD, kisspeptin administration significantly modulated brain ...

www.ncbi.nlm.nih.gov

Can anyone (@readalot ?) help me figure out what 1 nmol/kg of kisspeptin translates to in micrograms? That is the dose per hour they gave these men, for 1 hour and 15 minutes. I assume a subcutaneous shot of the same dosage would be a good starting point if I wanted to experiment with it.

Using kisspeptin-54 molecular weight (assume 5857 g/mol but there are various peptide lengths)....

1 nmol/kg/hr x 5857 ng/nmol x 1 mcg/1000 ng = 5.857 or ~ 6 mcg/kg/hr

 

[Cataceous]

Beat me to it. While it would be preferable to use kisspeptin-54, it's probably not very affordable compared to kisspeptin-10. Kisspeptin-10 is 1,302.4 g/Mol, so 1 nMol is 1.30 mcg.

 

[Nelson Vergel]

Kisspeptin Forum

https://www.excelmale.com/forum/tags/kisspeptin/ https://www.excelmale.com/forum/threads/kisspeptin-increases-penile-tumescence-and-sexual-brain-processing-in-men-with-hssd.26468/ https://www.excelmale.com/forum/threads/kisspeptin-suppression-under-trt-can-it-affect-mood-and-libido.21374/...

www.excelmale.com

 

[FunkOdyssey]

Oh, I didn't realize there were different forms of kisspeptin. That dose of kisspeptin-54 works out to around 500 mcg for me. From what I've seen, common kisspeptin-10 doses are something like 100 mcg daily. The lower dose for kisspeptin-10 looks like it is supported by some data from this study where 1 mcg/kg produced a stronger LH response than higher doses:

Kisspeptin-10 Is a Potent Stimulator of LH and Increases Pulse Frequency in Men

AbstractContext:. Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity,

academic.oup.com

 

[mcs]

In my first trial with KS-10, my total T levels increased 40% after a month on 100mcg/day (You can read about it on my previous post here) - but - I was also taking tesa/ipa/cjc which may have an influence on T levels as well. I am now awaiting the labs after upping the dose of KS-10 to 100mcg twice daily to see if I I get even more of a boost further.

 

[Art1h_]

In my first trial with KS-10, my total T levels increased 40% after a month on 100mcg/day (You can read about it on my previous post here) - but - I was also taking tesa/ipa/cjc which may have an influence on T levels as well. I am now awaiting the labs after upping the dose of KS-10 to 100mcg twice daily to see if I I get even more of a boost further.

Did you get the labs?

 

[mcs]

Did you get the labs?

Updated labs revealed slightly less on the TT but my FT went up substantially.

 

[Hyrulewarrior1978]

Where is everyone getting their kisspeptin from? If it’s from a random website like peptide sciences and not a pharmacy I’m not going to do that.

 

[DorianGray]

Where is everyone getting their kisspeptin from? If it’s from a random website like peptide sciences and not a pharmacy I’m not going to do that.

I believe Tailor Made Compounding has it. You would need a prescription from a physician that does business with them however.

 

[mcs]

Where is everyone getting their kisspeptin from? If it’s from a random website like peptide sciences and not a pharmacy I’m not going to do that.

I don't believe TMC has much of any injectable peptides available since the FDA investigation a couple years back and more recent product recalls. PS is the only one I trust now + the practitoner markups of pharma peptides are ridiculous. I have had thje PS peptides 3rd-party tested and all came out 99%+ pure.

 

[mcs]

Any concerns with KS-10 and its potential pro-atherogenic, pro-iflammatory downside that has been addressed before here?