How long does TRT take to show effects?

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Nelson Vergel

A review of studies attempted to determine the time-course of the effects induced by testosterone replacement therapy from their first manifestation until maximum effects are attained.

Causes of Low Testosterone and Benefits of Treatment

This review found that:

· Effects on sexual interest appear after 3 weeks plateauing at 6 weeks, no further increments beyond.

· Changes in erections/ejaculations may require up to 6 months.

· Effects on quality of life manifest within 3-4 weeks, but maximum benefits take longer.

· Effects on depressive mood appear after 3-6 weeks with a maximum after 18-30 weeks.

· First effects on erythropoiesis (increased red blood cells) after 3 months, peaking at 9-12 months.

· Prostate specific antigen and volume rise, marginally, plateauing at 12 months; further increase related to aging rather than therapy.

· Effects on lipids appear after 4 weeks, maximal after 6-12 months.

. Insulin sensitivity may improve within few days, but effects on glycemic control become evident only after 3-12 months.

· Changes in fat mass, lean body mass and muscle strength occur within 12-16 weeks, stabilize at 6-12 months, but marginally continue to improve over years.

. Effects on inflammation occur within 3 to 12 weeks.

· Effects on bone detectable after 6 months but continue at least for 3 years.

Onset of effects of testosterone treatment and time span until maximum effects are achieved


For information on how to prevent or reverse side effects of testosterone, click here:

Testosterone Side Effect Management Table

The following graph shows how many weeks it may take for maximum results
TRT benefits time of onset.jpg
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Defy Medical TRT clinic doctor

Nelson Vergel

Snyder PJ. Testosterone treatment of male hypogonadism. In: Matsumoto M,
Martin KA, eds. UpToDate. 2016. Accessed May 12, 2016

Scientific references on testosterone benefits

testosterone benefit references.jpg
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