How can one increase SHBG when it is too low?

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eli

Active Member
Yes, I have tried it all over the last 6 years. Daily doses, bi weekly, topical, injections, combination topical and injections, Test Prop, Test Cyp. It all feels like I am injecting water. Same with thyroid meds - they all feel like I am taking a placebo instead of any type of actual medication.

What if one in your situation got a liver transplant? Let's ignore the cost

I think your liver has something going on. I'm low shbg too, sometimes single digits but my problem with trt is managing e2, it's such a bitch with low shbg
 
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Charliebizz

Active Member
Yes, I have tried it all over the last 6 years. Daily doses, bi weekly, topical, injections, combination topical and injections, Test Prop, Test Cyp. It all feels like I am injecting water. Same with thyroid meds - they all feel like I am taking a placebo instead of any type of actual medication.
But in the past you said trt increases your energy and your terrible without it. So I would call that partial success no?

I have lowish shbg and I haven’t found any benefit from trt that I can nail down. The highest dose I tried was 120 a week and it gave me terrible anxiety and intrusive thoughts.
 

DJXS

New Member
I keep hearing people say that there are medications that can increase SHBG. When questioned, they back down.

Are there actually any medications that reliably increase SHBG?

- Estrogen is out of the question, because all of us with low SHBG already have high estrogen to begin with. The liver doesn't care.
- T3 is supposed to increase it, but if you believe the studies, you need to achieve hyperthyroid doses ~50 mcg per day to see a boost. Also, the studies are in people that start with normal SHBG, not impaired SHBG.

Capesaris is on the way as a drug to increase SHBG. It's a SERM that works at the liver.

Has anyone heard of anything else that might work?
I've heard that metformin can lead to increased SHBG, as well as vegetarian, and even better vegan, diet. But also that the keto diet can increase SHBG. More frequent injections will also help reduce crashing an already low SHBG. Good luck, fellow low-SHBGers!
 

ERO

Member
Lots of these things do raise SHBG but by a very tiny amount at most, so it's not enough to help low SHBG guys like us.
 

Ardoc2

Member
FWIW I have read lately that Non-alcoholic fatty liver can be a cause of low SHBG and that can happen without obesity or diabetes. Apparently some people (genetically) store fat excessively in their liver and it can be asymptomatic otherwise. I believe you need an ultrasound to determine fatty liver? I think it was an article on this site but i can't find it at the moment.
 

Vince

Super Moderator
My oldest sister has a fatty liver from eating carbs. Even though she's very slim.

Decrease of SHBG has a larger impact on the presence of NAFLD than MS. The odds ratios (ORs) and 95% confidence intervals (CI) for presence of MS (metabolic syndrome) and NAFLD (non-alcoholic fatty liver disease) with per one standard deviation (SD) decrease in SHBG (sex hormone-binding globulin) (SD = 17.27 nmol/L).

 

Graham

Member
Has anybody ever tried using enclomiphene to raise shbg? I read on another thread clomid raised it so I figured enclomiphene might do the same. I wonder if it works if shbg would stay up after discontinuing it.
 

Charliebizz

Active Member
I tried it for 8 weeks a few years back. It did nothing raise my SHBG.
Has anybody ever tried using enclomiphene to raise shbg? I read on another thread clomid raised it so I figured enclomiphene might do the same. I wonder if it works if shbg would stay up after discontinuing it.
Clomid did raise my shbg and my total t but ft stayed low. And my shbg went back down to low after I got off.
 
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