hCG induced Leydig apoptosis mitigated with TUDCA

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The authors S-J PARK et-al 2012 demonstrate a mechanism for hCG-induced endoplasmic recticulum stress leading to Leydig cell death in a mouse Leydig cell tumor line (in vitro ).

"In addition, TUDCA as a chemical chaperone and ER stress inhibitor can rescue hCG-induced ER stress-mediated apoptosis as well as restore production of steroidogenic enzyme and testosterone."

Tauroursodeoxycholic acid (TUDCA) is a naturally occurring bile acid found in humans in small amounts. Advocates suggest supplementation to cleanse and protect the liver, to protect neurons and more.

The cost of TUDCA as supplement is prohibitive to most. There is no evidence that hCG induces human Leydig cell apoptosis through this mechanism either.

Full article available for free review on the PDF link.
http://jme.endocrinology-journals.org/content/50/2/151
 

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