HCG and inflammation

Nelson Vergel

Founder, ExcelMale.com
Why would nature make women produce large amounts of hCG while pregnant? To ensure their health and their babies'.

"Human chorionic gonadotrophin (hCG) is the first specific molecule synthesized by the embryo. hCG RNA is transcribed as early as the eight-cell stage, and the blastocyst produces the protein before its implantation. hCG in the uterine microenvironment binds with its cognate receptor, luteinizing hormone/choriogonadotropin receptor (LHCGR), on the endometrial surface. This binding stimulates leukemia inhibitory factor (LIF) production and inhibits interleukin-6 (IL-6) production by epithelial cells of the endometrium. These effects ensure essential help in the preparation of the endometrium for initial embryo implantation. hCG also effects angiogenic and immunomodulatory actions as reported in many articles by our laboratories and other ones. By stimulating angiogenesis and vasculogenesis, hCG provides the placenta with an adequate maternal blood supply and optimal embryo nutrition during the invasion of the uterine endometrium. The immunomodulatory properties of hCG are numerous and important for programming maternal immune tolerance toward the embryo. The reported effects of hCG on uterine NK, Treg, and B cells, three major cell populations for the maintenance of pregnancy, demonstrate the role of this embryonic signal as a crucial immune regulator in the course of pregnancy. Human embryo rejection for hCG-related immunological reasons has been studied in different ways, and a sufficient dose of hCG seems to be necessary to maintain maternal tolerance. Different teams have studied the addition of hCG in patients suffering from recurrent miscarriages or implantation failures. hCG could also have a beneficial or a negative impact on autoimmune diseases during pregnancy. In this review, we will discuss the immunological impacts of hCG during pregnancy and if this hormone might be used therapeutically. "


In HIV, we found that HIV+ women who got pregnant had a decreased HIV viral load and their KS cancer spots disappeared. hCG is in fact a immune-modulator. Inflammatory cytokines are made by the body to actually heal. They are only damaging when produced in excess in the absence of injury.



 

Cataceous

Well-Known Member
Unless there's a problem with units it looks to me as though even the lowest concentration used in this experiment, 1 IU/mL, is hundreds of times greater than typical plasma levels seen in guys adding hCG to TRT, a few mIU/mL.

There are still some possible reasons to avoid doses that would equate to supraphysiological LH levels:
 

Seth

Member
Unless there's a problem with units it looks to me as though even the lowest concentration used in this experiment, 1 IU/mL, is hundreds of times greater than typical plasma levels seen in guys adding hCG to TRT, a few mIU/mL.

There are still some possible reasons to avoid doses that would equate to supraphysiological LH levels:
Interesting article on HCG
 

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