Chapter 12 - Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs

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Chapter 12 - Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs​

Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs

The function of the hypothalamo-pituitary-testicular-accessory organ axis is to ensure normal androgenization (including embryonic, infantile, puberta…

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From

Yen & Jaffe's Reproductive Endocrinology

Now celebrating its 40th anniversary, Yen & Jaffe’s Reproductive Endocrinology, 8th Edition, by Drs. Jerome F. Strauss III, Robert L. Barbieri, and An...

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For those who want more info on Fig. 12.6B:

https://journals.physiology.org/doi/prev/20171106-aop/abs/10.1152/ajpregu.00376.2003

PDF:

https://journals.physiology.org/doi/epdf/10.1152/ajpregu.00376.2003

System of ODEs to describe the testosterone compartments:

If you work through the math and characteristic times one can show that our best understanding does not support the statement that lowering SHBG under the constraint of constant exogenous T ester results in higher free T (as @Cataceous has so eloquently stated many times). Instead if you magically wave your SHBG wand and lower SHBG (or take some oxandrolone) the free T will stay the same and Total T will decrease (measured at peak or trough with accurate method).

 

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Discussion of fractional amplitude in case you are wondering what the heck that is.

https://journals.physiology.org/doi/full/10.1152/physiol.00027.2015

 

[Weasel]

Great stuff guys. This goes against 90% of everything you can find online. Even against the description from Nelsons discount labs website.

 

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Great stuff guys. This goes against 90% of everything you can find online. Even against the description from Nelsons discount labs website.

Thanks. My real-world example

Who's currently on T propionate?

The support is appreciated. Nonetheless, the goal here is to improve our knowledge. That can only occur when new ideas face close scrutiny and survive informed criticism. @DS3 was on point to bring up the subject of direct metabolism of bound testosterone. But his other comments are mainly vague...

www.excelmale.com

I may not ever use 17-AA AAS again but if I did I'd do a before and after using LC-MS/MS with ED instead of estimating with cfTV. Anyway you get the idea.

Another way to look at it:

Realistic TRT Recomp Progress

Thanks for sharing but this last entry doesn’t compute for me. This is Labcorp LC/MS for TT and fT with ED or Ultrafiltration? Given your TT and SHBG your FT should be around 50 ng/dL (about 2% fT/TT as your previous results) using Vermeulen method which tracks accurate free T reasonably well...

forums.t-nation.com

 

[equel]

This is all fine and dandy dude, I love it, actually. However, how about u use ur IQ to figure out why the hell i struggle so much on test with my low shbg (mainly libido), fix that for me and i will personally give u 2000 dollars atleast.

 

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characteristic times

Kinetics of Removal of Intravenous Testosterone Pulses in Normal Men

Testosterone (T) is secreted into the bloodstream episodically, putatively distributing into total, bioavailable (bio) [nonSHBG-bound] and free T moieties. The kinetics of total, bio and free T pulses are unknown.Adrenal and gonadal steroidogenesis was ...

www.ncbi.nlm.nih.gov

 

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This is all fine and dandy dude, I love it, actually. However, how about u use ur IQ to figure out why the hell i struggle so much on test with my low shbg (mainly libido), fix that for me and i will personally give u 2000 dollars atleast.

Hey brother, I don't practice medicine and if people could be cured by internet gurus we'd all be healed already by Danny Bossa. If I had a solution for you I sure wouldn't want any money, but I don't even have a solution for myself.

Thanks for the kind words and I wish you success on your journey.