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Navigating testosterone replacement therapy and hormone health can be overwhelming. Conflicting information, outdated medical advice, and unqualified opinions flood the internet. ExcelMale.com was created to cut through the noise — providing a rigorously moderated space where men share real experiences, backed by clinical research and guided by genuine expertise.

Whether you're exploring TRT for the first time, optimizing your current protocol, managing side effects like elevated hematocrit or estradiol, or seeking to preserve fertility with HCG therapy, our community offers the knowledge and support you need. We discuss everything from injection frequency and bloodwork interpretation to lifestyle factors that affect testosterone levels.

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A chemical engineer by training, Nelson has served as a key opinion leader for pharmaceutical companies on clinical research strategy, trained clinicians on hormone optimization protocols, and authored definitive guides including Testosterone: A Man's Guide & Beyond Testosterone. He founded DiscountedLabs.com to make lab testing accessible and built ExcelMale.com into a community where men find and share evidence-based answers.

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Applying testosterone gel on four sites increased T more than using one site
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They chose to apply on left and right arms/shoulders and left and right abdomen. Product used was Androgel 1%. Pharmacokinetics of Transdermal Testosterone Gel in Hypogonadal Men: Application of Gel at One Site VersusFour Sites: A General...
Cialis (Tadalafil) steady-state literature
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This paper is from 2010, but I'd like to draw attention to it as steady-state has been emphasized in threads about HRT. Reference Here are some things covered in this study: Steady state of tadalafil is reached after 5 days. This is...

The state of testosterone therapy since the FDA’s 2015 labelling changes about heart risks

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Table of Contents Reference: Clinical Endocrinology.2018;1–8. Summary Objective A label change in testosterone (T) products in March 2015 followed a highly publicized FDA advisory committee meeting in September 2014. Changes included a...

The FDA May Limit Access to Affordable hCG and FSH

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Table of Contents This is a critical issue that will greatly affect the compounding industry if it goes through. Basically no compounding pharmacy in the US will be allowed to make HCG (and other menotropins like FSH, HMG) at all. You...
Testosterone Myths Debunked By International Experts
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In order to address widespread concerns regarding the medical condition of testosterone deficiency (TD) or male hypogonadism, an international expert consensus conference was convened in Prague, Czechoslovakia on October 1, 2015. Experts included...
Sex Hormones and Fibromyalgia: The Pain Connection
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"In this study Younger measured testosterone, progesterone and estradiol levels as well as cortisol in 8 women with FM for 25 days straight while having them record their pain levels. He found that both progesterone and testosterone were...
Subclinical Hypothyroidism Causes Erectile Dysfunction
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Table of Contents The thyroid is a butterfly-shaped endocrine gland located in the lower front of the neck. It produces thyroxine or T4, which is converted to triiodothyronine, or T3. T4 production is controlled by thyroid stimulating...
Erectile Dysfunction 101 – Facts, Causes, and Management Options
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Table of Contents By Nick Gold Erectile dysfunction (also known more commonly as impotence or sexual dysfunction) is the inability to maintain a sufficiently rigid erection for a satisfying sexual experience. According to the Global Survey...

Liquid Chromatography/Mass Spectrometry is More Accurate for Hormone Blood Testing Than Older IAs

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Table of Contents Roli L, et al. J Endocrinol Invest. 2017. The steroid response to human chorionic gonadotropin (hCG) stimulation in men with Klinefelter syndrome does not change using immunoassay or mass spectrometry. Abstract Purpose...
Low Testosterone Causes and Benefits of Treatment
Men’s Heart Disease Partly Due to Low Estrogen
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The study was presented at the Endocrine Society's 97th annual meeting this month. In addition to finding that higher levels of testosterone led to lower HDL, and that estrogen didn’t affect HDL, Yu’s team found that low levels of estrogen led to...
Clinical Aspects of Gynecomastia in Adult Males: A Multicenter Study
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Table of Contents Clinical and Etiological Aspects of Gynecomastia in Adult Males: A Multicenter Study Gynecomastia, defined as the benign proliferation of breast glands in males, is a common complaint that produces anxiety and discomfort...

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