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    Dht as an intracrine and paracrine hormone

    I’m just curious: is it the high blood serum dht concentrations, or is it the higher free t from scrotal cream that contributes to hairloss, or is it a combination. A doctor on a particular Facebook group suggested that dht is more intracrine/paracrine, and so serum dht is essentially...
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    Hpta recovery unsuccessful

    I was on trt then got off and recovered successfully with clomid after four months. I then made the decision to get back on trt after I had fully recovered. It has been six months now and I can tell I’m still low t, and I’ve been struggling with the idea of getting on trt permanently but I...
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    Testosterone Cream Application without shutting down natural production

    I am considering trying to use the cream in a way that doesn’t shut down natural production. Maybe applying one click scrotally every three days or something like that. Does this even Make any sense?
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    David Sinclair’s supplement stack

    I’m currently taking alive by science nmn, resveratrol, and quercitin and I have noticed an improved mood in less than a week. Just wanted to share.
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    Question about possible FDA ban on compounded hormones

    I’m trying to decide whether or not I want to go back on trt. I’ve had the most success with scrotal cream (even though it was far from perfect but better than going without it). Other methods I’ve tried don’t work for me. I’ve tried injections and for some reason I don’t convert any of the...
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    Sleeping issues with injections

    This is my second attempt at trt. I’m currently on injection/cream protocol. My shbg is low so I was on 126mg cypionate per week initially which was too much for me. Now I’m down to 98 mg per week (daily shots) with one click cream to inner thigh to increase dht (since I’ve had low dht with...
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    Quest diagnostics free t range

    Quest tops off at 155pg\ml (15.5ng/dl) when it is generally considered (on this forum at least) that free t should be 20-30 ng/ml. So who’s right? Should we be aiming for a max of 15.5ng/dl?
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    Shortness of breath

    I just restarted t therapy about a month and half ago and recently developed fatigue, anxiety, some depression, and a weird feeling that feels like shortness of breath. A cough relieves that feeling temporarily. I think it’s high estrogen related because I donated blood and that didn’t fix the...
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    Restart after two years

    I was on trt for a little more than 2 years. Morning t readings were high 300s low 400s. I could not seem to get dialed in with cream or injection. My main complaint was inconsistent libido erections etc. I have been off for a little more than a month. I took clomid 25mg daily for the first 20...
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    Clomid trial

    I’ve been on trt for two years. Decided to get off a month ago due to not ever finding a protocol that work for me. I decided to try clomid. I started at 25mg then moved down to 12.5mg after being instructed to do so by defy. I was feeling better initially(great actually), but after being on it...
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    Androgel vs compounded cream

    I was wondering if androgel sustains levels of t longer than compounded creams. Why Do androgel and generics use gels instead of a cream base? Is there some scientific Evidence out there that say gels are slower release and more effective than creams? I’m not talking about scrotal application...
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    Ssri discontinued/libido ED problems

    I’ve been on T for two and a half years now with inconsistent libido (the cream being more beneficial than shots). Before I got on trt my sexual function was fine. Last year I took an ssri for about six months. I stopped taking it two months ago because I thought my ED was from the drug but I’m...
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    Testosterone Caused Folliculitis

    I went to the dermatologist after using testosterone cream and she diagnosed me as having folliculitis. I'm getting small itch bumps all over my body. anyone else experience this? is this a common side effect? Also, does this mean a weakened immune response? I keep reading that testosterone...
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    Applying cream twice a day problems

    To those of you applying cream BID, do you have sleep issues after applying the second dose at night. Cream seems to be very activating and I can’t sleep at night when I apply the second dose. If I just apply the morning dose I sleep fine. Anybody else have this issue ?
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    Still trying to find libido

    I’ve been on topical cream (not applied to testicles) and now shots. I was on the 100mg dose of cream and that brought my dht up but not my t. So I switched to shots. I’ve been taking daily shots now for 6 weeks at 150mg per week. My shbg is 15, e2 47, t-778, ft- 159 (max is 155). It seems one...
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    Just got my test results. Need advice

    I am on 100mg cypionate injection per week, injecting mwf. I tested Monday morning before shot and results are as follows: TT-495 Free t-125 (35-155) DHT 18 (16-79) Estradiol 23 Shbg 10 I feel better on injections but had a higher sex drive I think on the cream. I also had higher dht levels on...
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    Gel to injection switch

    I have been on trt since May. Levels at around 350 or so. First started with androgel, then switched to compounding cream, and just switched to injections this week using Pfizer depo. The cream at 100mg got me up to around 450 testosterone level during the day but then dropped back to 300 the...
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