Zinc supplementation improves fasting glucose in prediabetes

Nelson Vergel

Founder, ExcelMale.com
In a pilot, double blind, randomized controlled trial, Md. Rafiqul Islam, MD, of the Center for Clinical Epidemiology and Biostatistics at the University of Newcastle and the Hunter Medical Research Institute in Newcastle, Australia, and colleagues analyzed data from 55 adults with prediabetes identified from the Bangladesh Institute of Health Sciences Hospital database (mean age, 44 years; 28 men; mean baseline fasting blood glucose, 5.8 mmol/L). Researchers randomly assigned participants to 30 mg zinc sulfate (n = 28) or placebo (n = 27) once daily for 6 months. Participants received biweekly phone calls to check adherence to therapy. All participants completed an in-person interview and a 24-hour food frequency questionnaire, underwent blood draws, and received healthy eating and lifestyle advice. Primary outcome was reduction in fasting blood glucose level over 6 months; secondary outcomes included insulin resistance, insulin sensitivity, beta-cell function, serum zinc concentration and lipid profiles.


At 6 months, the zinc group had improved its mean fasting blood glucose concentration compared with both baseline (5.37 mmol/L vs. 5.8 mmol/L; P <.001) and placebo (5.37 mmol/L vs. 5.69 mmol/L; P < .001). Researchers also observed statistically significant improvements in beta-cell function, insulin sensitivity and insulin resistance.

Both groups saw serum zinc levels increase to equal levels of 67 ppb at 6 months, which researchers attributed to increased care and nutrition during the study period. No participants developed type 2 diabetes during the study period.
“Despite the small sample size, we demonstrate a real potential for zinc supplementation to improve glucose handling,” the researchers wrote. “This effect may be substantial enough to prevent or, at least, delay progression of prediabetes.” &#8211; by Regina Schaffer

http://www.healio.com/endocrinology..._medium=email&utm_campaign=endocrinology news
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
6
Guests online
456
Total visitors
462

Latest posts

Back
Top