Zinc May Halt the Progress of Diabetes

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Adults with prediabetes assigned to zinc supplementation are less likely to progress to type 2 diabetes compared with adults not assigned to supplementation, and supplementation may lead to reductions in fasting plasma glucose, 2-hour oral glucose tolerance test and insulin resistance, according to researchers in Sri Lanka.

  • Researchers evaluated data from 200 adults (mean age, 51.8 years; 43% men) with prediabetes randomly assigned to zinc 20 mg per day or placebo to determine the effect of zinc on glycemic control, other cardiometabolic and anthropometric parameters, and progression of disease.
  • Participants were enrolled between August 2012 and December 2016; the study duration was 12 months. Study visits were conducted at baseline, 1, 3, 6 and 12 months.
  • Type 2 diabetes developed in more participants in the placebo group compared with the zinc group (25% vs. 11%; OR = 2.7; 95% CI, 1.2-6.5). Reductions in FPG and 2-hour OGTT were observed in the zinc group but not in the placebo group. From baseline, insulin resistance decreased significantly at 6 and 12 months in the zinc group, but the decreases were not observed in the placebo group.

"Zinc Supplementation May Lower Diabetes Progression Risk," Journal of Diabetes, 2017, https://www.healio.com/endocrinolog...campaign=endocrinology news&m_bt=852809511235

 

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Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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