Wife's Thyroid Blood work

Smokin Joe

Active Member
I had my wife's blood work done to check her Thyroid functions as she has been feeling run down and not sleeping well.
I feel like that she may be a bit Hypothyroid but would appreciate other opinions.
She is two years Post menopausal but outside of that nothing out of the norm.
Our doctors keep telling us you are normal for your age and just getting old.
Anyway I would appreciate some help from the group in interpreting her results.
Thanks

Lab Corp
TSH, 2.72 - Range .450-4.50 uIU/ml
Thyroxine (T-4), 6.6 - Range 4.5-12.0 ug/dl
Triiodothyronine, Free, Serum, 3.1- Range 2.0-4.4 pg/ml
Thyroxine (T-4) Free Direct, S T4 Free Direct, 1.06 - Range .82-1.77 ng/dl
 
FT4 is at 25% of Reference Range, FT3 is at 45% of Ref. Range. Normally would like to see these fairly close together. Optimal would be having both in the 50% to 80% of Ref Range area, and ensuring to keep Reverse T3 ratio > 20.

Would like to see Reverse T3 and antibodies (TPO & TgAb). With the variance in reference ranges (FT3 at a higher level than FT4), could indicate pooling; meaning FT3 is stacking up a bit, not getting into the body efficiently. The RT3 lab will help to identify this possibility.

The problem with peri & post menopause is that estrogen dominance becomes a problem due to the steep decline in progesterone production. Dr. Uzzi Reiss has written extensively on this subject and how it can lead to severe adrenal problems. These adrenal issues will play into the thyroid, as cortisol plays a major role with getting T3 to the body.

Should probably be researched a little deeper with more labs (RT3, antibodies, 4x Saliva cortisol w/ DHEA correlation, iron/ferritin, electrolytes, D3), and reviewed with a specialist that has experience with this area of treatment. Don't accept the "normal for your age, and getting old" garbage.
 
Thanks Chris-I knew I could count on you.
Thyroid is new to me so I'll have to do my homework as it seems a bit confusing.
Will order the test recommended and post.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

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The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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