Why don't we test all hormones involved in testosterone synthesis?

There are a lot of hormones that are involved in testosterone synthesis, pregnenolone. androstenidone, progesterone.

I have never seen anyone on here post those results, if they are so important why don't any of the leading doctors test them?

Also I've never seen estrone or estriol tested, I assume this is due to lower potency? They might not be as strong as estradiol, but they still must be doing something?

If dhea and cortisol oppose each other, does having a naturally high DHEA level mean you have low cortisol? I don't understand how else it could be if they oppose eachother.
 
High cost, that's why...

Multiply DiscountedLabs costs by 3 since that is the regular prices most clinics use (So, approx $3000 )
I am not including aldosterone in this panel and other intermediary hormones.

hormones.webp

full panel.webp
 
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Also I've never seen estrone or estriol tested, I assume this is due to lower potency? They might not be as strong as estradiol, but they still must be doing something?

Per the Mayo Clinic's clinical laboratory: The two major biologically active estrogens in men and non-pregnant women are estrone (E1) and estradiol (E2). A third bioactive estrogen, estriol (E3), is the main pregnancy estrogen, but plays no significant role in non-pregnant women or men. E2 demonstrates 1.25 to 5 times the biological potency of E1 and thus is of genuine significance in the evaluation of male hypogonadism.
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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