Where can I find Kyzatrex? Low cost options

[firefighterinNC]

Hello there,

Just for clarity: You are getting 120 200mg pills for $135 per month? and when you say 90 day cost you mean $135 x 3 months? That is a great deal.

That is correct, EpiqScripts is where my doctor sent the Rx to. I was at MarleyDrug in NC and they were 179 for 120.

New Rx is 360 pills for $410

Old Rx sent to Marley was $90 a month that got me 60 pills to last 30 days

 

[madman]

Thats the game plan, the new pharmacy comes to 135$ a month for the 90 day cost. Not terrible but i'm hoping i can stretch that some by a lesser dose. I'm currently taking 600mg daily to use the rest of my 150mg pills up. Libido has suddenly seemed to increase in just the last 3 days i'm hopeful that my joint pain goes away and then all will be well.
I've seen user reports of people being on the 800mg daily and it gets them well over 2000TT. I don't need that much imo nor do i want to feel amped up like that again. My nervous system seems to have finally reset after coming off of injections. Oddly testicle size has increased some on Kyzatrex ( I guess its the non therapeutic dose lol)
I was going to give HCG a go but I have my doubts about the efficacy of the brand I bought so I have since thrown that out. I can reach out to my PCP and ask for lab work again I don't think she would mind.
It seems finding doctors that actually read the prescriber information and print out of drugs is few and far between.

Yes some outliers will hit a really high peak TT on the higher doses but keep in mind this is a short-lived daily peak as levels will start coming down fairly quick.

Most guys on injections are hitting high-end/high or in some cases absurdly high troughs whether injecting once weekly, twice-weekly, M/W/F, EOD or even daily.

T levels are jacked up 24/7 steady-state.

Oral TU is a different animal due to the PK as your daily peaks whether physiologic/supra-physiologic are short-lived followed by much lower levels 8-10 hrs post-dose (standard am/pm) protocol.

Troughs can end up close to/near baseline.

The body is never amped up on T 24/7 as you are hitting 2 daily peaks/troughs 7 days a week.

Smart move going with 300 mg BID to see where your levels end up.

Again you should be getting your bloodwork done 7 days after you started the new protocol (300 mg BID).

Hoping everything works out for you!

 

[madman]

That is correct, EpiqScripts is where my doctor sent the Rx to. I was at MarleyDrug in NC and they were 179 for 120.

New Rx is 360 pills for $410

Old Rx sent to Marley was $90 a month that got me 60 pills to last 30 days

Buy & Bill Prescriber Enrollment Form

epiqscripts.com

 

[firefighterinNC]

Yes some outliers will hit a really high peak TT on the higher doses but keep in mind this is a short-lived daily peak as levels will start coming down fairly quick.

Most guys on injections are hitting high-end/high or in some cases absurdly high troughs whether injecting once weekly, twice-weekly, M/W/F, EOD or even daily.

T levels are jacked up 24/7 steady-state.

Oral TU is a different animal due to the PK as your daily peaks whether physiologic/supra-physiologic are short-lived followed by much lower levels 8-10 hrs post-dose (standard am/pm) protocol.

Troughs can end up close to/near baseline.

The body is never amped up on T 24/7 as you are hitting 2 daily peaks/troughs 7 days a week.

Smart move going with 300 mg BID to see where your levels end up.

Again you should be getting your bloodwork done 7 days after you started the new protocol (300 mg BID).

Hoping everything works out for you!

yeah really the only downside i've seen thus far is what I feel like is joint pain from the Kyzatrex. I can't explain it, the doc says its joint pain from my levels not being high enough. So I don't really know what to believe in that aspect. Injections are certainly simpler imo. I'll see how it goes, I asked my PCP doctor if i can repeat labs next week as that will give me a full 7 days on the new dose. I want to make sure its worth it before I fork over the $ for a 90 day supply.


Sorry i'm not tracking on the PK? what is that?

As always appreciate you're help.

 

[madman]

yeah really the only downside i've seen thus far is what I feel like is joint pain from the Kyzatrex. I can't explain it, the doc says its joint pain from my levels not being high enough. So I don't really know what to believe in that aspect. Injections are certainly simpler imo. I'll see how it goes, I asked my PCP doctor if i can repeat labs next week as that will give me a full 7 days on the new dose. I want to make sure its worth it before I fork over the $ for a 90 day supply.


Sorry i'm not tracking on the PK? what is that?

As always appreciate you're help.

Yes you were hitting a dismal peak TT and more importantly FT.

Keep in mind healthy estradiol levels are critical for bones, joints, ligaments and tendons.




Kyzatrex (oral TU) is short-acting due to the PK.

A fairly short peak T level, time to maximum concentration (Tmax) will be achieved 3-5 hrs post-dose then levels will decline fairly quick followed by much lower levels at trough.

You will get 2 daily peaks/troughs.

Look over the differences in Cmax achieved fasted vs low vs moderate vs high fat meal.


PK

Due to the solubilizers for TU used in the formulation the PK profiles have a profile that allows for increases in AUC without exceeding limits on Cmax.




Absorption

The KYZATREX® self-emulsifying drug delivery system is well absorbed from the gastrointestinal tract. Both testosterone undecanoate and the newly formed 5-alpha-dihydrotestosterone undecanoate are absorbed via the lymphatic system, circumventing first passage through the liver.

Following oral administration an important part of the active substance testosterone undecanoate is co-absorbed with the lipophilic solvent from the intestine into the lymphatic system, thus partially circumventing the first-pass inactivation by the liver. KYZATREX® must be taken with a normal meal or breakfast to ensure absorption.

KYZATREX® is expected to produce testosterone concentrations that approximate normal concentrations seen in healthy men.

When KYZATREX® was given with breakfast containing 16%, 33%, and 45% fat, the exposure (AUC 0- 24 hr) of testosterone was increased by 37%, 87%, and 94%, respectively, compared to when given under fasted conditions. The primary efficacy and safety study was conducted under fed conditions regardless of the type of meals and the primary efficacy endpoint of achieving testosterone C avg in normal testosterone range was met.

There was no effect on testosterone PK when KYZATREX® was administered with 20% alcohol along with a high-fat meal versus a high-fat meal alone.

Distribution:

Administration of radioactively labelled testosterone undecanoate (3H-TU) to men resulted in radioactivity in the lymph associated with unmetabolized testosterone undecanoate and 5-alpha- dihydrotestosterone undecanoate. Peak levels of radioactivity appeared in the lymph and plasma 2.5-5 hours after administration. Circulating testosterone is primarily (around 40%) bound in serum to sex hormone-binding globulin, 2% remains unbound (free), and the rest is loosely bound to albumin and other proteins.




Metabolism:

It is metabolized partly in the intestinal wall into 5-alpha-dihydrotestosterone undecanoate (DHTU) and in plasma and tissues TU is hydrolyzed to free testosterone and DHTU to DHT. Free testosterone is rapidly converted to 5-alpha-dihydrotestosterone, androstenedione and estradiol.




Elimination:

The highest concentration of radioactivity in urine was found 2 hours later. During the first 24 hours approximately 40% of the administered dose was found in urine and the total recovery of the dose in urine during the first week was 45-48%.

 

[Nelson Vergel]

This is what a representative of the company said:

" ...we definitely have options for patients to get a RX sent in by their provider (where the patient pays vs having what the clinic charges).

If prescribers send it to either the pharmacy below...it will be $169/month. The prescribers don't need to sign up or anything, they just need to submit via EMR to Epiq's information below (include patient cell phone number) and Pharmacy will reach out to get it fufilled. "

 

[firefighterinNC]

Yes you were hitting a dismal peak TT and more importantly FT.

Keep in mind healthy estradiol levels are critical for bones, joints, ligaments and tendons.




Kyzatrex (oral TU) is short-acting due to the PK.

A fairly short peak T level, time to maximum concentration (Tmax) will be achieved 3-5 hrs post-dose then levels will decline fairly quick followed by much lower levels at trough.

You will get 2 daily peaks/troughs.

Look over the differences in Cmax achieved fasted vs low vs moderate vs high fat meal.


PK
View attachment 54805
View attachment 54806
View attachment 54807
View attachment 54808

Due to the solubilizers for TU used in the formulation the PK profiles have a profile that allows for increases in AUC without exceeding limits on Cmax.




Absorption

The KYZATREX® self-emulsifying drug delivery system is well absorbed from the gastrointestinal tract. Both testosterone undecanoate and the newly formed 5-alpha-dihydrotestosterone undecanoate are absorbed via the lymphatic system, circumventing first passage through the liver.

Following oral administration an important part of the active substance testosterone undecanoate is co-absorbed with the lipophilic solvent from the intestine into the lymphatic system, thus partially circumventing the first-pass inactivation by the liver. KYZATREX® must be taken with a normal meal or breakfast to ensure absorption.

KYZATREX® is expected to produce testosterone concentrations that approximate normal concentrations seen in healthy men.

When KYZATREX® was given with breakfast containing 16%, 33%, and 45% fat, the exposure (AUC 0- 24 hr) of testosterone was increased by 37%, 87%, and 94%, respectively, compared to when given under fasted conditions. The primary efficacy and safety study was conducted under fed conditions regardless of the type of meals and the primary efficacy endpoint of achieving testosterone C avg in normal testosterone range was met.

There was no effect on testosterone PK when KYZATREX® was administered with 20% alcohol along with a high-fat meal versus a high-fat meal alone.


View attachment 54809
Distribution:

Administration of radioactively labelled testosterone undecanoate (3H-TU) to men resulted in radioactivity in the lymph associated with unmetabolized testosterone undecanoate and 5-alpha- dihydrotestosterone undecanoate. Peak levels of radioactivity appeared in the lymph and plasma 2.5-5 hours after administration. Circulating testosterone is primarily (around 40%) bound in serum to sex hormone-binding globulin, 2% remains unbound (free), and the rest is loosely bound to albumin and other proteins.




Metabolism:

It is metabolized partly in the intestinal wall into 5-alpha-dihydrotestosterone undecanoate (DHTU) and in plasma and tissues TU is hydrolyzed to free testosterone and DHTU to DHT. Free testosterone is rapidly converted to 5-alpha-dihydrotestosterone, androstenedione and estradiol.




Elimination:

The highest concentration of radioactivity in urine was found 2 hours later. During the first 24 hours approximately 40% of the administered dose was found in urine and the total recovery of the dose in urine during the first week was 45-48%.

Sounds like a fatty meal it works best!
My doc doesn't think its the medication causing joint issues, but rather the lack of testosterone and e2 from the correct dose. We will see if it improves. Labs were ordered, i'll go next week as that will give me 7+ days at the 300mg BID

 

[madman]

Sounds like a fatty meal it works best!
My doc doesn't think its the medication causing joint issues, but rather the lack of testosterone and e2 from the correct dose. We will see if it improves. Labs were ordered, i'll go next week as that will give me 7+ days at the 300mg BID

Yes as I stated in my reply from post #14 that your issue with joint aches/pains most likely has to do with your T levels being tanked.

Even though you were started on too low a dose 150 mg BID you would have had issues with absorption seeing as you were having a hard time taking the capsules with a meal/enough fat.

Again the standard recommended starting dose is 200 mg BID and if you listen to any of the uros in the know who are treating men using Kyzatrex they would tell you that many tend to need the higher-end dose 300-400 mg BID to hit a high enough peak FT.

Dr. Sun who has treated 100s of men has most of them taking 300-400 mg BID.

Many are following his hybrid AM/NOON dosing protocol to maintain higher peak/trough earlier in the day!

The downfall for some. would be a low trough in the late evening/overnight but it gives the hpta a break!

 

[madman]

Thread 'Shifting the Testosterone Treatment Paradigm with Oral Testosterone (Kyzatrex)'

Apr 18, 2025

Again you heard it here first!

Nelson's domain the one and only!

Very informative webinar on the use of the newer oral TU formulations.

Testosterone therapy has long been dominated by injectable and topical formulations, but the landscape is evolving. This webinar explores how oral testosterone is redefining treatment protocols, offering a convenient and effective alternative. With recent clinical insights and real-world data, we’ll discuss why practitioners should reconsider their approach to testosterone replacement therapy (TRT)....

• madman
• hypogonadism; oral t; jatenzo; tlando; kyzatrex
• Replies: 35
• Forum: Testosterone and Men's Health Articles

• 

Standard protocol (morning/evening))

Dr. Suns hybrid protocol (breakfast/lunch)

 

[aj allday]

This is what a representative of the company said:

" ...we definitely have options for patients to get a RX sent in by their provider (where the patient pays vs having what the clinic charges).

If prescribers send it to either the pharmacy below...it will be $169/month. The prescribers don't need to sign up or anything, they just need to submit via EMR to Epiq's information below (include patient cell phone number) and Pharmacy will reach out to get it fufilled. "

View attachment 54810

So it is $169, regardless if its patient pay or clinic pay?

 

[firefighterinNC]

Seemed pretty painless for me, doctor called in a Rx, Epiq texted me asking for my info, I filled out my demographics and then about an hour later a bill came. Paid the bill after calling in to confirm it was for a 90 day supply, $409 later, they shipped it fedex 2 day delivery.

That comes out to $136 a month for me. I'm not sure where the price above is coming in at $169 as that was not my cost.

Edited* My hope is that I don't need the 800 mg dose daily and I can lower it some so that would actually come out even cheaper per month.

 

[aj allday]

Seemed pretty painless for me, doctor called in a Rx, Epiq texted me asking for my info, I filled out my demographics and then about an hour later a bill came. Paid the bill after calling in to confirm it was for a 90 day supply, $409 later, they shipped it fedex 2 day delivery.

That comes out to $136 a month for me. I'm not sure where the price above is coming in at $169 as that was not my cost.

Edited* My hope is that I don't need the 800 mg dose daily and I can lower it some so that would actually come out even cheaper per month.

Good point. The dosage is probably why the price is different. Thank you.

 

[firefighterinNC]

Good point. The dosage is probably why the price is different. Thank you.

Yeah I’m on the max dosage of Kyzatrex monthly or so I’m told. 400mg 2x daily.

I’d think the highest dosage would also net you the highest price but who knows anymore. Marley Drug was $80 for a 30 days supply but my dose was only 300mg daily or 60 pills a month.

The new dose is 120 pills a month. I’d give EpiqScripts high remarks though they were very easy to deal with even when I called in to verify.