When your testicles shut down?

Hi,

When excacly your testicles shut down when you're injecting testosterone? Does it depend on the quantity of testosterone that is being given? Or maybe they just completle stop working after whatever dose you will give and the only testosterone that is in your body is solely the synthetic one? Thanks.
 
~4 weeks of Exo T will result in shutdown, probably starts around week 2 as the body reacts to "seeing" that it has enough T and signals the Testes to stop making it.
 
~4 weeks of Exo T will result in shutdown, probably starts around week 2 as the body reacts to "seeing" that it has enough T and signals the Testes to stop making it.

And it doesn't matter what type of testosterone that it? (it's enanthate, though) Or how often do you inject it and in which quantity?
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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