What Most Men Don’t Know about the Risks of Testosterone Therapy

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By Stephanie Pappas

www.scientificamerican.com

More Men Are Taking Testosterone—Without Knowing the Health Risks

To boost mood and manliness, men are spending lots of money on the hormone testosterone—yet they may see trouble instead of benefits
www.scientificamerican.com www.scientificamerican.com


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Violet Frances; Source: Abraham Morgentaler (scientist reviewer)
 
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Thread 'What No One Tells You about Testosterone Replacement Therapy'


Testosterone replacement therapy (TRT) is exploding in popularity among men. TRT has been touted online as a cure-all for everything from low energy to poor mood and even as a way to increase masculinity itself. But how much of the buzz is backed by science? Host Rachel Feltman talks with journalist Stephanie Pappas about the realities behind the trend. They explore who truly benefits from TRT, the overlooked risks—including fertility loss—and the rise of private clinics offering testosterone.
 

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TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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