What is the optimum estrogen for artery health in men?

[tank77]

Hi guys,

Im huge on heart health with my TRT , am wondering what the healthy range if there is one of E2 should one aim for for endophelial health? Im in Australia and our guidelines only stipulate to be under 150 whatever that means ! we dont have a sensitive test either ....is there a T to E ratio I should strive for to know my TRT is being heart protective not destructive? have a big family HA history too so this bothers me and I want to nail it! Thx

 

[TLR]

There are studies showing different things in this area, but there are no ABSOLUTE answers to your question. And trying to get your estradiol to a specific, predetermined place is one of the most frustrating experiences you can attempt in my opinion. Get your T levels to a place where you feel your best, let your estrogen land where it lands and leave it alone unless you become symptomatic, then take the LOWEST dose of AI you have to for symptom relief. Many times this can be avoided by simply lowering the dose and / or increasing frequency.

 

[abe]

When it comes to coronary disease and estrogen, I wouldn't be concerned. If you're concerned about your heart health, I would investigate a heart CT scan. Get a calcium scoring and see if you have any plaque in your arteries.

 

[tank77]

When it comes to coronary disease and estrogen, I wouldn't be concerned. If you're concerned about your heart health, I would investigate a heart CT scan. Get a calcium scoring and see if you have any plaque in your arteries.

Abe, thing is Estrogen is cardio protective, too little and the endothelium we get endothelial dysfunction which leads to degradation of the arteries ! its a big part of the puzzle...my CAC was 5 btw but my heart Ct with contrast showed a 20-40% stenosis of my LAD ....so in my case little calcium fair bit more soft plaque !

 

[Vince Carter]

That's the million dollar question with no answer, can't seem to be answered, different for every guy. You can work it backwards though from high Estrogen (negative) symptoms and try ways to reduce that alleviate those symptoms and that should be an area for E that is healthy, for YOU.

 

[Nelson Vergel]

No one has been able to answer that question. I would say enough estradiol to keep good lipids while your T is over midrange. 0.3-0.4% of T aromatizes to E2 for balance.

Men’s Heart Disease Partly Due to Low Estrogen

 

[xqfq]

tank77, Dr. Thomas O'Connor has some good videos on YouTube about heart health on TRT.

I'm also very much into cardiovascular health (and now on TRT). The HRT / estrogen studies in women (HERS, WHI) didn't show a cardiovascular benefit, but I believe there may have been flaws with studies (synthetic estrogens and too late of an intervention for the women). But it's not a sure thing that more estrogen means more cardioprotection.

I would agree with Nelson that you should monitor your lipids and see what gives you an improvement. You will probably want to get an ApoB & Apo A1 panel or an NMR lipid panel rather than a traditional lipid panel.

It seems there's no great drugs for raising the function of HDL right now, but given the amount of research and understanding / rate of progress, it's bound to happen soon (I hope!)