Weight loss and Naltrexone

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We used it for years back in the dark days of HIV as an immune booster without much luck.

There are companies studying it as a treatment to reduce food cravings. This study used a combination of Naltrexone and Wellbutrin with good results. However, Wellbutrin can be too stimulating for some people causing anxiety and irritability. In HIV we did not have side effects with Naltrexone, so it seems to be a safe drug. If it worked well enough by itself they would not be combining it with an antidepressant (just my opinion)

"Combination naltrexone-sustained release (SR) 32 mg and bupropion SR 360 mg (NB32) is a fixed dose drug combination under investigation as a treatment for obesity.[SUP]5[/SUP] Bupropion is approved for marketing in the United States for depression and smoking cessation. Functionally, bupropion is thought to increase the level of dopamine (DA) activity at specific brain regions, which appears to lead to a reduction in appetite and increase in energy expenditure. Bupropion is used in the treatment of depression not only for its clinical efficacy but also because of its side effect profile, which includes modest weight loss.[SUP]6[/SUP] Bupropion is also used as a treatment for smoking cessation, and ongoing trials are evaluating its utility to treat other types of drug addictions.[SUP]7 [/SUP]Naltrexone is approved in the United States for the treatment of opioid addiction and for the treatment of alcoholism. Naltrexone works by blocking opioid receptors in the brain and inhibits the reinforcing aspects of addictive substances, reducing their perceived reward.[SUP]8[/SUP] Naltrexone might also decrease reward sensitivity to natural reinforcers as shown by reports of reduced reward to sweet-tasting foods in opioid addicts treated with naltrexone.[SUP]9[/SUP] Moreover, the combination of naltrexone and bupropion has been demonstrated to result in greater weight loss compared with either agent alone.[SUP]5[/SUP] " Source: http://www.nature.com/ijo/journal/vaop/ncurrent/full/ijo2013145a.html

Diabetes Care. 2013 Oct 21. [Epub ahead of print]
Effects of Naltrexone Sustained- Release/Bupropion Sustained Release Combination Therapy on Body Weight and Glycemic Parameters in Overweight and Obese Patients With Type 2 Diabetes.Hollander P, Gupta AK, Plodkowski R, Greenway F, Bays H, Burns C, Klassen P, Fujioka K; for the COR-Diabetes Study Group.
[h=3]Source[/b]Baylor Medical Center, Dallas, Texas.

[h=3]Abstract[/b]OBJECTIVE
To assess the efficacy and safety of 32 mg naltrexone sustained-release (SR)/360 mg bupropion SR (NB) in overweight/obese individuals with type 2 diabetes with or without background oral antidiabetes drugs.

RESEARCH DESIGN AND METHODS This was a 56-week, double-blind, placebo-controlled study in which 505 patients received standardized lifestyle intervention and were randomized 2:1 to NB or placebo. Co-primary end points were percent weight change and achievement of &#8805;5% weight loss. Secondary end points included achievement of HbA1c <7% (53 mmol/mol), achievement of weight loss &#8805;10%, and change in HbA1c, waist circumference, fasting blood glucose, and lipids.

RESULTS In the modified intent-to-treat population (54% female, 80% Caucasian, and mean 54 years old, weight 106 kg, BMI 37 kg/m2, and HbA1c8.0% [64 mmol/mol]), NB resulted in significantly greater weight reduction (-5.0 vs. -1.8%; P < 0.001) and proportion of patients achieving &#8805;5% weight loss (44.5 vs. 18.9%, P < 0.001) compared with placebo. NB also resulted in significantly greater HbA1c reduction (-0.6 vs. -0.1% [6.6 vs. 1.1 mmol/mol]; P < 0.001), percent of patients achieving HbA1c <7% (53 mmol/mol) (44.1 vs. 26.3%; P < 0.001), and improvement in triglycerides and HDL cholesterol compared with placebo. NB was associated with higher incidence of nausea (42.3 vs. 7.1%), constipation (17.7 vs. 7.1%), and vomiting (18.3 vs. 3.6%). No difference was observed between groups in the incidence of depression, suicidal ideation, or hypoglycemia.

CONCLUSIONSN B therapy in overweight/obese patients with type 2 diabetes induced weight loss, which was associated with improvements in glycemic control and select cardiovascular risk factors and was generally well tolerated with a safety profile similar to that in patients without diabetes.
 
I presented my GP w/ a couple of the recent studies, posted above, and we are giving it a shot. I have lost 7 lbs. in 6 days w/o trying and for the first time in decades I'm not feeling controlled, for lack of a better word, by food. Took the kids trick-or-treating = huge loot and haven't had the urge once. Nothing short of remarkable to me.
 
I never use Naltrexone for my weight loss. I don't use any diet pills or medication for the weight control purposes because I believe on the natural method of the weight control. Using these diet pills or weight control supplements can cause some side effects for the health.

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Last edited:
Lombard said:
I never use Naltrexone for my weight loss. I don't use any diet pills or medication for the weight control purposes because I believe on the natural method of the weight control. Using these diet pills or weight control supplements can cause some side effects for the health.
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Lombard, Naltrexone is not a diet pill in the sense that most think. It blocks opiate receptors and inhibits a dopamine dump (from my understanding) that many food addicts experience. Recent research has clearly demonstrated, with the use of fMRI scans that many, if not most, obese people have an increased dopamine level similar to that of Crack addicts just from visual food cues. With this drug it's as if a switch has been turned off in my brain. I for the first time am not getting high or low from food and only look at it as fuel. I do not plan to use this drug indefinitely and Naltrexone alone will not make me lose weight but rather it allows for behavior modifications to take place.
 
robs2nd75 said:
Speaking of which, Marco, do you recall any negative/positive sides? If you don't mind sharing what was your dose?
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Sorry, didn't see this before.

Dose was 3mg custom compounded. Before was using an injectable version. No sides I could tell. I felt a mild sedative effect from it though. Nothing else. Would like to try again. I wonder if it would help reduce CRP?
 
Nelson Vergel said:
Is Naltrexone the only drug you can link your weight loss to?
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I'm on the combination of naltrexone and bupropion (wellbutrin). They do not sell the doses that are listed in above study so I have to break pills and come as close as possible. I'm on 300 mg bupropion and 25 mg naltrexone as 37mg was way to high and I experienced some rather bizarre side effects that quite frankly wouldn't be worth it. I was on wellbutrin in the past at the same dose and it did nothing for my weight. I don't think Naltrexone alone would be beneficial as I have found it to be sedating and think it could lead to depression. The combo however has been nothing less than remarkable. I have no doubt that this will become a treatment of choice for those suffering from an eating disorder. I am exercising less, eating less, and have a heightened sense of awareness. I am aware of every bite going into my mouth, the texture, the taste and still have a temporary high for maybe a second or two (not a min. or two as before). The only other change is an increase in Testosterone from 150mg to 200mg started same week as naltrexone combo but, the initial 4-5 lbs of the 6lbs of loss I reported was before starting T increase.
So to answer your question, its a combination, but I definitely believe Naltrexone is the driving force.
 
Marco N Cognito said:
Sorry, didn't see this before.

Dose was 3mg custom compounded. Before was using an injectable version. No sides I could tell. I felt a mild sedative effect from it though. Nothing else. Would like to try again. I wonder if it would help reduce CRP?
Click to expand...

CRP???? and 3mg is extremely low at least compared to study but be cautious as higher dose caused me some pretty severe dizziness.
 
I found this interesting study on naltrexone and morning erections

Treatment of Idiopathic Erectile Dysfunction in Men with the Opiate Antagonist Naltrexone—A Double-Blind Study
Journal of Andrology >
Vol 14 Issue 6 >
ABSTRACT Opiate antagonists can indirectly stimulate the secretion of luteinizing hormone (LH) and testosterone, as well as sexual functions in animals and humans. We therefore treated 20 otherwise healthy men with idiopathic erectile dysfunction aged 46.3 ± 2.7 years (mean ± SE, range 23.9–63.3) in a double-blind study with an opiate antagonist, naltrexone, or placebo. The erectile dysfunction of these men had persisted for 3.6 ± 0.5 years despite libido maintenance; standard procedures had excluded any organic causes. Trial duration was 12 weeks overall. After a 4-week forerun, the patients received at first 25 mg naltrexone/day orally or placebo for 4 weeks followed by 4 weeks of a 50-mg dose of naltrexone/day or placebo. Each day the patients filled out a questionnaire detailing libido, degree of erection, frequency of sexual intercourse, and spontaneous morning erections. Serum concentrations of gonadotropins and testosterone were determined radioimmunologically in the initial stage and at the end of each phase. Both patient collectives had similar initial factors. The group treated with naltrexone showed a significant rise in spontaneous early morning erections during the treatment: from 2.8 ± 0.3 to 4.2 ± 0.3 a week (P < 0.001). The placebo group showed no significant change in spontaneous erections (2.4 ± 0.3 and 2.6 ± 0.3, respectively). The subjective parameters, however, such as libido, degree of erection, and frequency of sexual intercourse showed no significant difference within each group. There was no difference in LH, follicle-stimulating hormone, or testosterone concentrations in both groups.

Thus, treatment with naltrexone significantly raises the rate of spontaneous early morning erections when compared to controls. Other parameters, especially those of the frequency of sexual intercourse, were not significantly influenced by the dosage of the administered opiate antagonist The significance of the naltrexone-induced rise in spontaneous morning erections requires more evaluation in a greater collective of patients with idiopathic erectile dysfunction.
 
That's really interesting. I assumed my improved morning erections were due to a better TRT protocol but it may be due to naltrexone.
 
My libido has know improved as well. I read a PCT program and saw Naltrexone listed. Why would anyone use naltrexone as a part of PCT????
 
Beyond Testosterone Book by Nelson Vergel
Could you post more information on LDN, your protocol, cost, doctor, compounding pharmacy and any other benefits.
 
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