Vitamin K is associated with a reduced risk of cardiovascular, cancer, or all-cause mortality

[Vince]

Intake of menaquinone was inversely related to all-cause mortality . https://www.ncbi.nlm.nih.gov/pubmed/15514282
.
Increase in dietary intake of vitamin K is associated with a reduced risk of cardiovascular, cancer, or all-cause mortality in a Mediterranean population at high cardiovascular disease risk.
http://jn.nutrition.org/content/144/5/743
.
Clinical Nutrition has published a new long-term study that explores if there is a relationship between intake of phylloquinone and menaquinones (vitamins K1 and K2, respectively) and all-cause and cause-specific mortality. The results showed that high intake of menaquinones (vitamin K2) was associated with a reduced risk of CHD (coronary heart disease) (at least in hypertensive participants), while high intake of phylloquinone (vitamin K1) was not associated with any reduced risks.
Vitamin K intake was not associated with all-cause mortality, cancer mortality and mortality from other causes.

http://www.clinicalnutritionjournal.com/article/S0261-5614(16)30216-3/abstract

http://www.bodyscience.com.au/blog/...-shown-again-to-impact-cardiovascular-health/

 

[rhino5169]

Heads up if you're taking plavix, it diminishes absorbtion.

 

[Gene Devine]

Vit K is an amazing vitamin in soooo many ways. You need it if you're supplementing calcium or else calcium will just stay in serum and never synthesize into bone density.

I take it religiously.

Also is huge in blood clotting factors...which is great for women who bruise easily.

 

[rhino5169]

I just re read what I wrote. I guess I was tired so it didn't come out right.
Vitamin K reduces the effect of plavix. If you're taking plavix I think it's pretty important that it's doing its job.

 

[Vince]

Plavix is a drug that thins the blood by reducing platelet aggregation. It has nothing to do with vitamin K. Warfarin/coumadin is a blood thinner that works by reducing vitamin K recycling in the liver, which reduces production of the vitamin K dependent proteins that make blood coagulate. Vitamin K supplements do not affect the action of plavix, aspirin, or other platelet aggregation reducing medications. They do affect the action of vitamin K antagonists like warfarin/coumadin.

 

[rhino5169]

Vitamin K & Plavix. ... Some vitamins may interfere or enhance the effects of medications. Plavix, for example, is a prescription medication that affects blood clotting and taking vitamin K, a vitamin necessary for blood to clot, may affect the biological activity of Plavix.


"Medications classified as anticoagulants, such as warfarin, act directly on vitamin K within the body to prevent the formation of blood clots. Although Plavix, classified as an antiplatelet medication, does not directly interact with vitamin K to prevent the formation of blood clots, you should avoid large fluctuations in vitamin K intake while taking any medication to treat clotting disorders. "
http://www.livestrong.com/article/459092-vitamin-k-plavix/

 

[Vince]

Think of it this way: Vitamin K1 (not K2) allows normal coagulation. Plavix blocks (an aspect of) platelet function.
In other words, the K1/K2 do not counteract the platelet-blocking effect of Plavix.

 

[rhino5169]

I will look more into this.
Thanks Vince

 

[Gianluca]

Vitamin K increase clotting, how about TRT and elevated H&H and the intake of supplemental vit K? I understand the benefits but it scares me to increse the chance to get a blood clot for high HH

 

[Vince]

The improvement in insulin sensitivity due to vitamin K2 intake is important. Excess insulin contributes to the formation of soft arterial plaque.
We know that The vitamin K-dependent matrix Gla-protein (MGP) is a potent inhibitor of arterial calcification.
https://www.ncbi.nlm.nih.gov/pubmed/18841280
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4555157/
https://www.ncbi.nlm.nih.gov/pubmed/9052783?
Coronary plaque on average is about 20% calcified and 80% non-calcified but some people have plaque which is 100% non-calcified.

 

[rhino5169]

Interesting.
When you say calcified do you mean hardened areas of plaque on the arterial walls?
If so, my dr wants me to be on a statin not so much for the lipid benefits but he says that it will harden any soft deposits, and that when they are soft there is a chance of rupture causing heart attack or stroke.

 

[Gianluca]

after all research I'm still not comfortable of taking Vit K along with TRT, despite its benefits

 

[Vince]

I agree, that calcified plaque is stable plaque, less chance of rupturing and causing a heart attack or stroke.

 

[rhino5169]

He wants me on 20mg pravastatin.
I've been reluctant because in the last 1.5 years i've been able to get myself off all past meds - 4 insulin shots a day, metformin, lipitor, ramipril, aspirin, to name a few.

I dont want to go back to any meds if possible, but im rethinking the pravastatin, just dont want to deal with the sides.

 

[Vince]

He wants me on 20mg pravastatin.
I've been reluctant because in the last 1.5 years i've been able to get myself off all past meds - 4 insulin shots a day, metformin, lipitor, ramipril, aspirin, to name a few.

I dont want to go back to any meds if possible, but im rethinking the pravastatin, just dont want to deal with the sides.

do you have a plaque score, the doctors I see will only put you on a statin if you have plaque

 

[rhino5169]

do you have a plaque score, the doctors I see will only put you on a statin if you have plaque

I dont know if I have a score, I probably do but didnt know there was one to check. I have 2 stents, first one put in my late 30's.

 

[Vince]

CT heart scan to check plaque, if you have artery stents. You can't have a CT scan to check artery plaque, stents block image. It sounds like you need a statin, only my opinion.

 

[rhino5169]

CT heart scan to check plaque, if you have artery stents. You can't have a CT scan to check artery plaque, stents block image. It sounds like you need a statin, only my opinion.

Thanks Vince.
I've been on the fence but have been leaning towards giving it a go but keeping an eye for side effects. I dont want to take a step backwards, but i'd also rather not have a heart attack.

Opinion on Vit K2 even though I have stents and am on Plavix?

 

[rhino5169]

I keep seeing things like this:

"- Blood thinners. Vitamin K reduces the effectiveness of blood thinning medications and should not be taken if you are on a medication like Coumadin (warfarin) or Plavix."

 

[Gianluca]

from my research, blood thinners work by blocking vit K so that the blood becomes thin, in the other hand blocking Vit K will result in plaque deposit in the arteries, I read this from Lifextention....

I keep seeing things like this:

"- Blood thinners. Vitamin K reduces the effectiveness of blood thinning medications and should not be taken if you are on a medication like Coumadin (warfarin) or Plavix."