Venous Thrombotic Events With Testosterone Therapy

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The Fountain of Youth

 

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1940 NEJM

1953 NEJM

 

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* poorly designed papers that were retrospective in nature and didn't have placebo controlled trials

 

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* only 4 of over 200 articles suggested any kind of relationship between cardiovascular disease with testosterone testosterone

* Giovanni Corona 20 RCTs and did a meta-analysis and showed there was no causal role between testosterone supplementation and development of adverse cardio and vascular events

* Sharma in a retrospective review of 83 000 men from the VA found that men on TRT vs no treatment had decreased all cause mortality and also the incidence of MI and strokes

* the T2DM study which looked at patients over 6 years, 581 men and you can see on the far right that those patients that were treated with testosterone had a much better likelihood of surviving than vs those untreated patients

* Hudson provided a meta-analysis of 35 placebo controlled trials that did up to 2017 and found no evidence or significant increased risk of cardiovascular disease between TRT and placebo and this is the largest individual analysis of T-Trials to date (2022)

* both the AUA and Endocrine Society have stated that there is no evidence that supplementation of testosterone increases cardiovascular risk

 

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