Mansour Razminia, MD, a cardiac electrophysiologist at Northwestern Medicine, discusses the innovative technique of fluoroless pulsed field ablation (PFA) for treating atrial fibrillation. He explains how this ultra-rapid electrical field safely disrupts targeted cardiac tissues, leading to effective treatment outcomes with minimal collateral damage. Dr. Razminia also highlights Northwestern Medicine's recent success with the procedure and introduces the retrospective MANIFEST-US survey designed to assess the acute efficacy and safety of the FARAWAVE™...
Could that cup of coffee or glass of wine change your cardiac risk? At this Medical Grand Rounds, we will present the latest evidence regarding the impact of common habits like alcohol and caffeine consumption on cardiac arrhythmias. In addition to exploring the clinical and lifestyle implications of our findings, we will describe some of the pioneering research methods we’re employing at UCSF to better understand the impact of lifestyle on heart health.
Speaker
Gregory M. Marcus, MD, MAS, is a professor of Medicine at UCSF...
I'm Dr Neil Skolnik. Today we are going to talk about the 2023 American College of Cardiology/American Heart Association guidelines for atrial fibrillation (AF). AF is common and is often first identified in the primary care office. AF substantially increases the risk for stroke, dementia, myocardial infarction, and heart failure.
When AF is detected, three areas of care need to be addressed: symptoms, stroke risk, and modifiable lifestyle factors. Patients with AF should have an echocardiogram done as well as laboratory tests (CBC, CMP...
* Together, these observations add an important piece to the complex puzzle of how sex hormones influence atrial electrophysiology. In this context, the principle “dosis sola facit venenum” (the dose makes the poison) resonates strongly, suggesting that apparent discrepancies between studies may not be contradictory, but rather reflect different positions along the testosterone spectrum which seems to be non-linear.
Figure 1. Illustration depicting the hypothesized dose-dependent U-shape relationship between testosterone and atrial fibrillation risk and the...
* our meta-analysis stands as the most up to date analysis restricted to RCTs directed to men aged 40 or older.
* The main fndings were as follows: (1) there were no significant diferences between groups in all-cause mortality, cardiovascular mortality, MI, and stroke; (2) TRT signifcantly increased the incidence of cardiac arrhythmias; (3) TRT was associated with decreased levels of HDL-c; and (4) there was a marginal increase in SBP levels in the TRT group.
Long‑Term Cardiovascular Safety of Testosterone‑Replacement Therapy in Middle‑Aged and Older...
Heart palpitations and AFIB (Atrial Fibrillation) risk in older men using testosterone is examined in the video below.
Highlights
[] Testosterone use in older men and its link to heart palpitations and AFIB.
[] Research findings suggest a potential association between testosterone therapy and heart rhythm disturbances.
[] Discussion about the need for cautious testosterone administration in older male patients.
[] Insights into the mechanisms through which testosterone might impact heart health.
[] Examination of existing studies to assess the credibility of the...
1 - Northwestern University, Feinberg School of Medicine
2 - The Brady Urologic Institute, Johns Hopkins School of Medicine
Introduction:
Secondary analyses of the Testosterone Replacement Therapy for Assessment of Long-Term Vascular Events and Efficacy Response in Hypogonadal Men (TRAVERSE) trial revealed significantly higher rates of new-onset atrial fibrillation...
Predict estradiol, DHT, and free testosterone levels based on total testosterone
⚠️ Medical Disclaimer
This tool provides predictions based on statistical models and should NOT replace professional medical advice.
Always consult with your healthcare provider before making any changes to your TRT protocol.
ℹ️ Input Parameters
Normal range: 300-1000 ng/dL
Predicted Hormone Levels
Enter your total testosterone value to see predictions
Results will appear here after calculation
Understanding Your Hormones
Estradiol (E2)
A form of estrogen produced from testosterone. Important for bone health, mood, and libido.
Too high can cause side effects; too low can affect well-being.
DHT
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth,
prostate health, and masculinization effects.
Free Testosterone
The biologically active form of testosterone not bound to proteins.
Directly available for cellular uptake and biological effects.
Scientific Reference
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.