UCLA’s Hair Growth Breakthrough: The Science Behind PP405 & the Future of Baldness Treatment

[madman]

What are the researchers saying about expectations?

* Professor Lowey is careful about that, he''s clear no such product will work for everyone, that's just biology right, everyone is different but he does stress that those first human trials they ran down in Orange County they were very encouraging and of course larger trials are needed they are still coming

UCLA scientists may have just revolutionized the future of hair loss treatment. In this episode, we explore the groundbreaking discovery of PP405, a small molecule that awakens dormant hair follicle stem cells — leading to full hair regrowth.

Backed by promising early human trials, this innovation goes far beyond the limited results of traditional treatments. Discover how Professors William Lowry, Heather Christofk, and Michael Jung are reshaping the field of regenerative medicine — and how their spinout company, Pelage Pharmaceuticals, is racing toward FDA approval.

 

[madman]

Pelage's PP405 Demonstrates Efficacy in Phase 2a Trial for Androgenetic Alopecia

PP405 shows promise for hair regrowth in phase 2a trial, with 31% seeing >20% density increase; phase 3 studies are planned for 2026.

www.dermatologytimes.com

Key Takeaways

• PP405 demonstrated safety and efficacy in a phase 2a trial for androgenetic alopecia, meeting primary endpoints without systemic absorption.

• The therapy targets the primary biological pathway of hair growth, differing from current treatments that focus on secondary causes.

• In the study, 31% of men showed over 20% hair density increase, with PP405 inducing new hair growth in previously bald areas.

• Pelage Pharmaceuticals plans to start phase 3 studies in 2026, aiming to advance PP405 as a regenerative hair loss therapy.