TRT effectiveness declining

amarziotta

New Member
Hello there
I have been in testosterone 200 mg weekly, 100 mg two times s week before I was feeling awesome, lot of strength you name it, since a year ago I start losing strenght a lot, I do not feel the same energy as before, looks like my body does not absorbed, results are ok, 1200 total and free maybe high like 400. My libido is Ok, but my muscle mass and weight dropped like 8 pounds. I increased the dose to see if something change but is about the same, maybe a bit more but nothing to be consider. Any suggestion, I take testosterone and gh, from the pharmacy and t4. Any suggestions
 
Last edited by a moderator:
Hi and welcome to Excel Male.

Without blood work it's impossible to tell what your problems are.

If you have you're latest blood work can you post complete with lab ranges and we'll jump in to help you!

G
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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