TRT and immune system

[sh1973]

I watched a video yesterday on YouTube with Dr. Mark Gordon and he brought up how TRT improves immune system function. Thinking back since I started TRT nearly a decade ago I’ve hardly ever gotten sick. In fact I don’t know when the last time was that I had a cold or any kind of virus. I didn’t get sick much prior to TRT but it seems it’s made it nearly non existent. Just curious if others have noticed this. BTW the video with Dr Gordon on the lifting dermatologist is a very informative video that certainly sheds light on some of the issues guys have with TRT.

 

[sebastian_r]

Same here.
Before TRT I got a cold / sick 3-4 times a year for 2-3 weeks each.
Haven't been sick on TRT once in several years.
Even all of my allergies are gone.

 

[sh1973]

I hadn’t really thought much about it over the years but after watching that video my wife and I were talking last night and man I cannot remember at all the last time I got any kind of sickness. I always try to find any positive aspect of things and I can certainly say the sure seems to be one.

 

[Systemlord]

BTW the video with Dr Gordon on the lifting dermatologist is a very informative video that certainly sheds light on some of the issues guys have with TRT.

I watched that video as well, too many guys are prescribe TRT without enough testing.

 

[sh1973]

Yes I agree systemlord and over dosed.

 

[Cataceous]

The research seems to be largely unfavorable:
High-Testosterone Men Have the Weakest Immune Responses
(PDF) Anabolic androgenic steroids effects on the immune system: A review
Mayo Clinic Discovers One Mechanism For Why Men And Women Differ In Immune Response
The effect of testosterone replacement treatment on immunological features of patients with Klinefelter's syndrome

 

[sh1973]

The studies are interesting for sure but it could be the increase in estradiol that goes hand-in-hand with testosterone replacement that strengthens some guys immune system‘s. There’s certainly something different with me as far as getting sick on TRT,no doubt about it.

 

[themud]

Same here.
2 1/2 years and haven’t gotten sick and my life long high bp went down.

 

[captain]

Talking about TRT not women and males that are not on TRT. Using info from them wouldn't say much about what happens in men on TRT.

One thing that happens with TRT is upstream hormones fall. DHEA is one of them and it boost immune function. This is not going to show in a study with non TRT users. So if your on TRT and not supplementing DHEA you may be reducing immune function. This could be why DHEA is not recommended for people with HIV.

 

[madman]

I watched a video yesterday on YouTube with Dr. Mark Gordon and he brought up how TRT improves immune system function. Thinking back since I started TRT nearly a decade ago I’ve hardly ever gotten sick. In fact I don’t know when the last time was that I had a cold or any kind of virus. I didn’t get sick much prior to TRT but it seems it’s made it nearly non existent. Just curious if others have noticed this. BTW the video with Dr Gordon on the lifting dermatologist is a very informative video that certainly sheds light on some of the issues guys have with TRT.

Do Androgens Modulate the Pathophysiological Pathways of Inflammation? Appraising the Contemporary Evidence

 

[sh1973]

Thanks madman, very good articles.

 

[Nelson Vergel]

Testosterone administration in men differentially increases neutrophil and monocyte counts. These findings, together with its erythropoietic effects, suggest that testosterone promotes the differentiation of hematopoietic progenitors into the myeloid lineage. These findings have potential mechanistic, therapeutic and safety implications.

Differential effects of testosterone on circulating neutrophils, monocytes, and platelets in men: Findings from two trials - PubMed

Testosterone administration in men differentially increases neutrophil and monocyte counts. These findings, together with its erythropoietic effects, suggest that testosterone promotes the differentiation of hematopoietic progenitors into the myeloid lineage. These findings have potential...

pubmed.ncbi.nlm.nih.gov

 

[Nelson Vergel]

Does Testosterone Suppress the Immune System?

This question is raised out of the confusion over the use of the term “steroid.” When somebody is having pain or inflammation and their physician prescribes them a “steroid” or something “steroidal”, they are prescribing a corticosteroid (like prednisone) to decrease inflammation. These can...

www.excelmale.com

 

[GreenMachineX]

At what point would testosterone reduce immune function? I'm about to get a Covid and flu test as I feel like garbage. I've switched from 25mg eod test cyp to 10mg ED and feel even better (aside from being sick of course). My last test results on 25mg eod were:
Total Testosterone 880 (250-1100)
Free Testosterone 210.4 H (35-155)

I haven't had bloodwork done on the daily dosing yet, but is that free test high enough to suppress health immune function on the eod dosing? I would imagine my current dose would be a little lower blood levels then that.

 

[GreenMachineX]

@Nelson Vergel @Systemlord @Cataceous

 

[Systemlord]

I haven't had bloodwork done on the daily dosing yet, but is that free test high enough to suppress health immune function on the eod dosing?

The last dosage increase 8 weeks ago did suppress my immune function slightly, lots of mucus and coughing that would seem to come and go. It's mostly gone now even as the weather is getting colder.

I can't remember the last time I had these issues, I haven't had the flu since I was 14 and am almost 50. I never get sick, brother and father are the same.

 

[GreenMachineX]

The last dosage increase 8 weeks ago did suppress my immune function slightly, lots of mucus and coughing that would seem to come and go. It's mostly gone now even as the weather is getting colder.

I can't remember the last time I had these issues, I haven't had the flu since I was 14 and am almost 50. I never get sick, brother and father are the same.

Are your levels within range, or slightly high?

 

[Systemlord]

Are your levels within range, or slightly high?

Back when I started Jatenzo my Total T levels were 479 ng/dL and my hematocrit was 55.9% and hemoglobin 18.7. My SHBG is 12.

Total T levels that are in range can be deceptive, my Total T can be in the 600's and Free T supraphysiological.

 

[GreenMachineX]

Back when I started Jatenzo my Total T levels were 479 ng/dL and my hematocrit was 55.9% and hemoglobin 18.7. My SHBG is 12.

Total T levels that are in range can be deceptive, my Total T can be in the 600's and Free T supraphysiological.

That's the situation I'm in. My free T is much higher than typical for my total. This covid is just dragging on too. Day 10. Started ivermectin yesterday. Done playing around.

 

[GreenMachineX]

For anyone still reading this thread, ivermectin knocked out my covid symptoms in days. Literally, 1 symptom gone per day until all gone.