Transdermal HRT for Women: Best Bet for Lower VTE Risk

Nelson Vergel

Founder, ExcelMale.com
When a blood clot breaks loose and travels in the blood, this is called a venous thromboembolism (VTE). The abbreviation DVT/PE refers to a VTE where a deep vein thrombosis (DVT) has moved to the lungs (PE or pulmonary embolism).

"Among different types of hormone replacement therapy (HRT), a transdermal formulation appeared safest in terms of venous thromboembolism (VTE) risk, according to researchers in England.

In a retrospective analysis of about 80,000 women who experienced VTE and some 390,000 non-VTE control women, 7.2% of VTE patients were exposed to HRT within 90 days of the index date compared with 5.5% controls, according to Yana Vinogradova, PhD, of the University of Nottingham, and colleagues.



But there was no added risk for VTE associated with HRT patches, gel, or subcutaneous formulas (adjusted odds ratio 0.93, 95% CI 0.87-1.01), they wrote in BMJ."

Source
 

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⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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