Well, you're definitely hypogonadal. What's of striking interest is your sky-high SHBG. It's clearly binding your free testosterone, which doesn't appear to have been repeated in the second test (why?). You made some general comments about how you're feeling, but can you tell us more? How long have you had the issues you presented with? Any history of steroid use? What medications and supplements are you taking?
I'm from the UKWhat country are you in?
Well, you're definitely hypogonadal. What's of striking interest is your sky-high SHBG. It's clearly binding your free testosterone, which doesn't appear to have been repeated in the second test (why?). You made some general comments about how you're feeling, but can you tell us more? How long have you had the issues you presented with? Any history of steroid use? What medications and supplements are you taking?
When we speak of secondary hypogonadism we only mean the problem isn't testicular in nature; the issues lie somewhere else. The pituitary, some other axis problem, possibly rooted in a thyroid irregularity, or cortisol. That said, your labs suggest that it is secondary hypogonadism. Your LH being low and your FSH being below the midrange means your body is not signaling for those hormones in excessive amounts. Your testicles are fine.
You can't really raise or lower SHBG, you play the hand you're dealt. Injections of androgen typically lower it, and if you were to initiate TRT larger, less frequent doses of testosterone would probably be prescribed.
There are more tests needed before any therapy should start. Have you ever had a full thyroid workup? Not just TSH, but ft3, ft4, rt3, and both antibody panels? Your history suggests issues long in the making; I would certainly zero in on thyroid. Many men complain of TRT failure but never have their thyroid evaluated. I'd also look at prolactin, at a minimum.
Predict estradiol, DHT, and free testosterone levels based on total testosterone
This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.
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A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.
The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038