This NMN Supplement Hype

[albert88]

Hi All,

I'm a healthy 39 year old but am noticing a few things changing. Such as sleep quality, recovery time, etc.

Without getting into details about my regime - I wanted to know - is a supplement like this worth it?

https://www.amazon.com/dp/B09PQG6ZB7?m=A16HK3XO0U61VI&ref=mpc_asin_image&th=1

I have a coupon to reduce the price to $60 - but before I even spend that, I want to get the input of this forum.

 

[albert88]

Also I am in no way affiliated with that product. I just saw it listed on sale through DealNews. Not sure if we can post that type of link!

 

[Cataceous]

It's one of a multitude of supplements that show some promise. However, there's not enough information at this point to tell whether long-term use is beneficial. It could even end up being harmful. At least the short-term safety profile looks reasonable. Arguably it makes more sense for older guys to gamble on such things. You've got more time to wait for additional research. "Further clinical trials have been launched to investigate the safety and benefits of NMN."[R]

 

[tareload]

I can save you a bundle even off the $60 bucks...

Nicotinamide

Nicotinamide, also known as niacinamide, is a water-soluble amide form of niacin or vitamin B3. It is found in foods such as fish, poultry, eggs, and cereal grains. It is also marketed as a dietary supplement, and as a non-flushing form of niacin.

www.mskcc.org

500 mg nicotinamide tabs are dirt cheap. Read the provider info above. Some dermatologists recommend to prevent skin cancer.

As pointed out above and in other threads, long term risk of supplementing is unknown.

For example:

Nutricost Niacinamide (Vitamin B3) 500mg, 240 Capsules - Non-GMO, Gluten Free, Flush Free Vitamin B3 https://a.co/d/1iSU5rh

Unless you have condition that makes risk to reward balance favorable I would tread lightly.

 

[tareload]

Comparison of metabolic fates of nicotinamide, NAD+ and NADH administered orally and intraperitoneally; characterization of oral NADH - PubMed

Since NADH has been implicated in medication for some symptoms and as a possible supplement for health, we characterized the metabolic fate of NADH orally given to mice by comparing with those of nicotinamide (Nam), NAD+ and NADH intraperitoneally or orally administered. Mice were individually...

pubmed.ncbi.nlm.nih.gov

 

[tareload]

https://www.researchgate.net/figure/Fig-1-Mammalian-NAD-metabolic-pathways-Nicotinic-acid-Na-nicotinamide-Nam-and_fig1_23796698

 

[tareload]

Related thread with @FunkOdyssey 's great points.

See references therein.

A study finds that high fish consumption is associated with an increased risk of melanoma.

The incidence of malignant melanoma was 22% greater among individuals whose median daily consumption of fish was 42.8 grams as compared to those whose median daily intake was 3.2 grams, according to researchers from Brown University. Additionally, they discovered that individuals with a median...

www.excelmale.com

 

[sammmy]

Hype created by Sinclair and a scam by companies that in many cases do not even sell real NMN. Read the negative reviews on Amazon about "NMN" products. They tell the real story. Don't be a lab rat for an untested compound. That's why FDA banned it, to actually do proper studies of the hyped up claims that Sinclair throws around.

 

[albert88]

Damn scam artists LOL! Everyone out for a buck! Thank you SO much for the info guys.

 

[Hyrulewarrior1978]

Hype created by Sinclair and a scam by companies that in many cases do not even sell real NMN. Read the negative reviews on Amazon about "NMN" products. They tell the real story. Don't be a lab rat for an untested compound. That's why FDA banned it, to actually do proper studies of the hyped up claims that Sinclair throws around.

You’re right that Sinclair is a scam artist, or close to one, but you’re wrong about why the FDA banned NMN:

 

[Nelson Vergel]

Amazon Bans Anti-Aging Supplement | Alliance for Natural Health USA - Protecting Natural Health

The internet retailer has removed supplements containing NMN, a promising longevity nutrient, from its store. Will other stores follow suit? Action Alert! Earlier this month, Amazon, the world’s largest retailer, decided it would no longer sell supplements containing nicotinamide mononucleotide...

anh-usa.org

 

[t_spacemonkey]

been taking this for 6+ months or so. hard to gauge. it seems to improve skin a bit and energy as well. been trying pulse this to see if difference can be felt. Sinclair is part of a pharma company which petitioned the FDA to ban it. pure monetary reason since they work on a drug which essentially is NMN. i don't like or listen to Sinclair at all. never trust a vegan lol

 

[Nelson Vergel]

been taking this for 6+ months

How does the power taste?

 

[t_spacemonkey]

How does the power taste?

powder? a little sour with a hint of sweet i think

 

[Nelson Vergel]

Thank you. I guess you won't be able to buy in the near future at Amazon.
I took NMN but all I felt was worsening of my body heat, which is pretty high usually. I stopped it.

 

[t_spacemonkey]

i've heard. amazon mid-march. then directly from the producers site, unless the FDA sends them threatening letters. thats what they said on the makers site....

 

[jlnosnih]

I've only been using NMN for a couple of weeks and my experience has been very positive. My energy level has increased dramatically as well as improvements in mood and sleep quality. From what I've read there's fake NMN being sold and if anyone wants to try it, I suggest reading the Amazon reviews and narrowing it down to products with 4.5 stars. Then read individual reviews submitted by verified purchase of the product. It may or may not be efficacious for you. I'm a 'senior citizen' which would indicate that my NAD levels were very low. So what's effective for me, might not be effective for someone else. I hope that the FDA doesn't ban this as a supplement, resulting in it becoming available only by prescription being sold at an inflated price.
My only advice to others is to Google NMN and read reviews from reputable sources such as the NIH National Library of Medicine website.

The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule - PMC

www.ncbi.nlm.nih.gov

Abundant Evidence for Anti-aging and Health-Enhancing Effects of NMN​

In numerous mouse models of disease and aging, NMN has demonstrated a wide array of remarkable effects, benefitting conditions ranging from diabetes to Alzheimer’s disease to ischemia.27 Orally administered NMN is quickly synthesized into NAD+ in tissues in mice. NMN has been able to suppress age-associated weight gain, enhance energy metabolism and physical activity, improve insulin sensitivity, improve eye function, improve mitochondrial metabolism and prevent age-linked changes in gene expression."

 

[Guided_by_Voices]

A few tidbits:

- Apparently one of the keys to actual benefits of NAD+ is maintaining the body's ability to recycle it, which is done by all the usual suspects, predominantly exercise. There is a video on Bitchute all about this.
- Apparently very small doses of Niacinamide create an NAD+ precursor, but larger amounts can be counter productive. I cut a gel-cap open and gradually use a tiny amount at a time.
- There are tons of other compounds that are likely as helpful (e.g. rapamycin, all the things in the book The Kaufman Protocol, the things in Perfect Health Diet, sunshine, etc.) that are at least as important important and less expensive.

 

[bhoffman]

I have been taking NMN and other longevity supplements since early 2020 and have similar experiences to yours. Added to this list is increased energy, faster healing of cuts and wounds, and faster hair and nail growth.

A few times in the past few years, I have gone off of NMN and not experienced much negative, but when I go back on, I feel the same increased energy that I did when I first started, so this shows the benefits are real and continuing.

More recently, David Sinclair has come over as a very divisive person, especially after the proposed FDA ban on NMN, I do, however, thank him and his book for getting me onto NMN it has changed my life for the better.

One important note for everyone taking or considering taking NMN David Sinclair recently very quietly stated that he now only takes 500mg of NMN daily, whereas before stated in his book (page 304) that he took 1,000 mg daily, this new daily dosage is line with a recent study that estimated the effective dosage of NMN based on weight, I created the following NMN dosage calculator that uses the findings from this study and can say that for people with average weight a daily dosage of 500 mg aligns very closely with this study. Here is the calculator NMN Dosage Calculator

Also, here is the video where he states that he now only takes 500mg daily of NMN

 

[Gman86]

I have been taking NMN and other longevity supplements since early 2020 and have similar experiences to yours. Added to this list is increased energy, faster healing of cuts and wounds, and faster hair and nail growth.

A few times in the past few years, I have gone off of NMN and not experienced much negative, but when I go back on, I feel the same increased energy that I did when I first started, so this shows the benefits are real and continuing.

More recently, David Sinclair has come over as a very divisive person, especially after the proposed FDA ban on NMN, I do, however, thank him and his book for getting me onto NMN it has changed my life for the better.

One important note for everyone taking or considering taking NMN David Sinclair recently very quietly stated that he now only takes 500mg of NMN daily, whereas before stated in his book (page 304) that he took 1,000 mg daily, this new daily dosage is line with a recent study that estimated the effective dosage of NMN based on weight, I created the following NMN dosage calculator that uses the findings from this study and can say that for people with average weight a daily dosage of 500 mg aligns very closely with this study. Here is the calculator NMN Dosage Calculator

Also, here is the video where he states that he now only takes 500mg daily of NMN

Do u take TMG alongside the nmn?

and do u take the nmn all at once on an empty stomach?

and is ur nmn in a powder or liposomal form?