The Hormonal Hype: Unmasking Androgens in Acne

[madman]

Very thorough worthy of a sticky!

 

[madman]

OBJECTIVES:

 

[madman]

The Complex Role that HORMONES play in the Pathogenesis of Acne Vulgaris

 

[madman]

4 PILLARS OF ACNE PATHOGENESIS

* Follicular Keritanization

* Inflammation

* C.Acnes

* Excess sebum production...due to Androgens

 

[madman]

Would steer clear of isotretinoin or any of the 5ARs (finasteride/dutasteride) due to side-effects (sexual/neurosteroids)!

Downfall here is isotretinoin is the most effective medication for treating acne especially moderate-severe cystic acne which can be devastating for many!

The need to prevent/minimize permanent scarring is critical!




* the only therapy that hits all 4 PILLARS with just one product is isotretinoin (Accutane) and we know that is the most effective treatment on the market today




TABLE. IMPACT OF TOPICAL AND ORAL MEDICATIONS ON FACTORS OF ACNE PATHOGENESIS

 

[madman]

SO...WHICH HORMONES ARE THE CULPRITS??

5AR activity/sensitivity of the hair follicle to DHT would be key here!


* Testosterone, DHT (5 times more potent than Testosterone!) and DHEA are the MOST POTENT ANDROGENS that we have within our bodies




HORMONES THAT CAUSE ACNE:

 

[madman]

HYPERANDROGENISM IN FEMALES: CAN BE CAUSED BY OVARIAN OR ADRENAL FACTORS

 

[madman]

Very serious condition some women face!



POLYCYSTIC OVARIAN SYNDROME

Pathophysiology of PCOS

 

[madman]

HORMONES ARE RESPONSIBLE FOR ALL STAGES OF ACNE

 

[madman]

Infantile Acne

INFANTILE ACNE:

TREATMENT FOR INFANTILE ACNE:

 

[madman]

Definitely all about the ANDROGENS here!




Pre-Teen & Puberty

PRE-TEEN & PUBERTY:

TREATMENT OF PRE-TEEN & PUBERTY ACNE VULGARIS:

CABTREO (clindamycin phosphate, adapalene, and benzoyl peroxide).

Second most effective medication to treat acne that tackles 3 of the 4 pillars!

Start your acne treatment with CABTREO

A first-of-its-kind 3-in-1 topical acne treatment. For ages 12+.

www.cabtreo.com

Efficacy and Safety of Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel: Post Hoc Analysis by Baseline Disease Severity - PubMed

ClinicalTrials.gov identifier NCT03170388, NCT04892706, NCT04214639, and NCT04214652.

pubmed.ncbi.nlm.nih.gov