The Facts and Unknowns on How Testosterone Impacts Prostate Health

madman · Jul 10, 2025

Is testosterone therapy a friend or a risk to your prostate?

In this eye-opening episode of the Dr. Geo Prostate Podcast, Dr. Geo sits down with Dr. Thomas Masterson — a leading urologist at the University of Miami, renowned for his expertise in male infertility, sexual health, and testosterone therapy.

They dive deep into one of the most controversial questions in men’s health: Does testosterone therapy harm your prostate?

Together, they explore:

* The science behind testosterone and its impact on the prostate

* Myths vs. facts about testosterone replacement therapy (TRT)

* How testosterone affects fertility and what you need to know before starting TRT

* The connection between testosterone, prostate enlargement (BPH), and prostate cancer

* Insights from the groundbreaking TRAVERSE trial

* Real-world patient scenarios and how doctors make clinical decisions

Chapters

00:00 How Testosterone Impacts Prostate Health
04:00 The Science Behind Testosterone and Sperm Production
14:19 Testosterone Therapy and Prostate Health
15:23 Exploring Testosterone and BPH
18:05 Benefits and Risks of Testosterone Therapy
35:52 Patient Options and Side Effects
36:45 PSA Screening and Family History
37:14 Testosterone Therapy and Prostate Cancer Risk
37:47 History and Myths of Testosterone
38:19 The TRAVERSE Trial and Cardiac Events
39:04 Critique of the TRAVERSE Trial
44:21 Testosterone Therapy for Hypogonadism
56:01 Testosterone After Prostate Cancer Treatment
01:03:43 Final Thoughts and Contact Info

madman · Jul 10, 2025

38:19 The TRAVERSE Trial and Cardiac Events
39:04 Critique of the TRAVERSE Trial

madman · Jul 10, 2025

Thread 'Prostate Risk and Monitoring During TRT'

Jun 16, 2024

ABSTRACT

Men with hypogonadism have reduced risk of prostate cancer mortality; whether testosterone treatment increases the risk of prostate safety events in men with hypogonadism remains controversial. Several studies including four larger randomized trials — the Testosterone Trials, TEstosterone and Atherosclerosis Progression in Aging Men (TEAAM) Trial, Testosterone for Diabetes Mellitus Trial, and Testosterone Replacement therapy for Assessment of long-term Vascular Events and efficacy ResponSE in hypogonadal men (TRAVERSE) Trial — treated men with testosterone or placebo for...

Thread 'Testosterone Replacement Therapy in Men with Prostate Cancer'

Jun 15, 2024

Lesson 20

Update Series (2024): Audio Playlist | AUA University

auau.auanet.org

Thread 'Testosterone Therapy May Be Reasonably Offered to Men on Active Surveillance for Prostate Cancer – Pro/Con'

May 11, 2024

AUA 2024: Crossfire: Controversies in Urology: Testosterone Therapy May Be Reasonably Offered to Men on Active Surveillance – Pro/Con

AUA 2024, Testosterone Therapy, prostate cancer, prostate cancer progression, TRAVERSE trial, managing testosterone deficiency in men with prostate cancer under active surveillance.

www.urotoday.com

(UroToday.com) Recent developments in urology have increasingly challenged the once prevalent notion that testosterone therapy exacerbates prostate cancer (PCa) progression. Dr. Abraham Morgentaler, in the latest session of the Crossfire: Controversies in Urology series, highlighted a significant shift over the past three decades, moving from a global...

madman · Jul 10, 2025

Thread 'Revisiting Death by Testosterone? We think not!'

Jun 15, 2024

Revisiting Death by Testosterone? We think not!

www.androgensociety.org

In July 2023 the cardiovascular results of the TRAVERSE trial were published in the New England Journal of Medicine, demonstrating conclusively that the use of testosterone therapy (TTh) in T-deficient men was associated with no increased risk of major adverse cardiovascular events (MACE), consisting of myocardial infarction, stroke, or cardiovascular death [ 1]. These results confirm the findings of other large randomized controlled trials (RCT) and observational studies and should finally lay to rest the...

post #2

Thread 'The Shocking Link Between Erectile Dysfunction and Heart Attacks'

May 12, 2024

*ED is a progressive disease

*15% of men with ED experience a cardiovascular event, like a heart attack or stroke, within seven years.

Renowned expert Dr. Mo Khera sheds light on common sexual dysfunctions in both men and women, emphasizing the startling connection between erectile dysfunction and heart attacks.

We delve into testosterone, exploring why low levels might not always warrant treatment and the importance of considering symptoms alongside testosterone levels for therapy decisions. The conversation extends to female...

Thread 'TRT and Cardiovascular Disease'

Feb 18, 2022

Testosterone replacement therapy and cardiovascular disease (2022)
Jeremy M. Auerbach and Mohit Khera

The use of testosterone therapy has a complex history of apprehension and questions regarding its safety. Despite an eventual consensus that testosterone therapy was safe and effective, several studies relating to cardiovascular risks emerged in the last decade, rekindling skepticism regarding the safety of testosterone therapy. Given the utility of testosterone therapy in treating the symptoms of hypogonadism, it remains crucial to closely examine the safety of testosterone...

madman · Jul 10, 2025

Thread 'Innovation in male fertility care with Larry Lipshultz'

May 5, 2025

Discover groundbreaking insights in urology as Larry Lipshultz, MD, shares innovative research and strategies for male fertility challenges.

Pearls & Perspectives: Innovation in male fertility care with Larry Lipshultz, MD, at AUA 2025

Discover groundbreaking insights in urology as Larry Lipshultz, MD, shares innovative research and strategies for male fertility challenges.

www.urologytimes.com

In this episode of Pearls & Perspectives from Urology Times, host Amy Pearlman, MD, sits down with the legendary Larry Lipshultz, MD, professor of Urology at Baylor College of Medicine and a pioneering figure in the field of andrology.

Recorded at the American Urological Association's...

madman · Jul 24, 2025

Thread 'Prostate Cancer - Active Surveillance: Past, Present, and Future'

Jul 24, 2025

* the truisms are that most men die with rather than of prostate cancer, if you live long enough almost all men will get a couple of cancer cells in the prostate

prostate cancer active surveillance.webp

Dr. Matthew Cooperberg takes us on a candid journey through Active Surveillance for prostate cancer—starting with its earliest days in the 1990s, through the ups and downs of PSA screening and treatment trends, and into today’s era of MRI, genomic tests, and AI-guided risk assessment.

This presentation is particularly exceptional, delivered as Dr. Cooperberg...