The Evolution of Testosterone Products in the U.S. (1935-2025)

Thanks to Dr Sun for this diagram.


Timeline details (left → right)

Year	Product (image above/below the line)	Form & delivery
1935-1937	No product image—text block below the line: “Testosterone first synthesized” with a bullet list of early preparations (oral 17α-methyltestosterone, injectable esterified, 17β-hydroxy testosterone, subdermal pellets).	—
1979	Depo®-Testosterone (vial & carton)	intramuscular injection of testosterone cypionate
1995	Androderm® (square purple patch package, shown below the line)	transdermal patch
2000	Androgel® (blue box)	transdermal gel
2014	Natesto	nasal gel
2018	Xyosted® (auto-injector pen)	subcutaneous injection / autoinjector – testosterone enanthate
2019	Jatenzo® (white bottle with orange capsules)	oral capsules – testosterone undecanoate
March 2022	Tlando® (three identical white bottles)	oral capsules – testosterone undecanoate
July 2022	KYZATREX® (three bottles in differing strengths with tablets scattered)	oral capsules – testosterone undecanoate

 

Thread 'FDA- Approved Testosterone Products in the United States- 2024'

May 28, 2024

Here are short descriptions for each of the FDA-approved testosterone products listed:

ANDRODERM​

Androderm is a transdermal patch that delivers testosterone through the skin. It is applied nightly to the back, abdomen, upper arms, or thighs and is worn for 24 hours.

ANDROGEL​

AndroGel is a topical gel applied to the skin, typically on the shoulders, upper arms, or abdomen. It is used to treat men with low testosterone levels.

ANDROID 10, ANDROID 25, ANDROID 5​

These are oral testosterone products that were used to treat testosterone deficiency but have been discontinued due...

• Nelson Vergel
• testosterone products testosterone treatments trt products trt treatments types of testosterone
• Replies: 1
• Forum: Testosterone Basics & Questions

• 

 

Thread 'Testosterone Products: Oral, Transdermal, Injectable, and More'

Jan 28, 2014

From the book: Testosterone: A Man's Guide



Testosterone Formulations

In theory, testosterone replacement should approximate the body's own natural production of the hormone. The average male produces 4 to 7 mg of testosterone a day with higher plasma levels in the early morning and lower levels in the evening. Women produce around a 12th of those rates.

Testosterone replacement is usually a lifelong commitment. It is a decision that should not be made without a discussion with your healthcare provider...

• Nelson Vergel
• Replies: 24
• Forum: Testosterone Basics & Questions

• 

 

1889 - 2019