Testosterone and prostate cancer have a complex relationship. In this video from the ISSM and Movember, Dr. Gerald Brock interviews Dr. Mohit Khera on testosterone supplementation after prostate cancer treatment. They discuss the latest understanding of testosterone’s role, the risks of low testosterone, its prevalence, and how to manage testosterone levels and PSA monitoring in prostate cancer survivors.
* For clinicians considering TTh in men after prostate cancer treatment, several considerations should guide decision-making. Patient selection is critical with regular monitoring, with close attention to PSA velocity and testosterone levels. The benefits of treating hypogonadism, including improvements in energy, sexual function, bone density, body composition, and potentially cardiovascular health, must be weighed against the theoretical risk of promoting occult cancer cells in each individual patient. The current literature suggests that TTh can be safely...
* Gaps in long-term data and areas for further research are identified, underscoring the need for careful application in clinical practice. This paper emphasises a multidisciplinary approach in patient selection, rigorous monitoring protocols, and fully informed decision-making. By presenting a comprehensive review of the evidence, we aim to clarify the role of TRT in improving quality of life for men in remission from prostate cancer, while ensuring that oncological safety remains the highest priority.
Table 1 Comparison of TRT Guidelines from BSSM, AUA, and EAU...
Predict estradiol, DHT, and free testosterone levels based on total testosterone
⚠️ Medical Disclaimer
This tool provides predictions based on statistical models and should NOT replace professional medical advice.
Always consult with your healthcare provider before making any changes to your TRT protocol.
ℹ️ Input Parameters
Normal range: 300-1000 ng/dL
Predicted Hormone Levels
Enter your total testosterone value to see predictions
Results will appear here after calculation
Understanding Your Hormones
Estradiol (E2)
A form of estrogen produced from testosterone. Important for bone health, mood, and libido.
Too high can cause side effects; too low can affect well-being.
DHT
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth,
prostate health, and masculinization effects.
Free Testosterone
The biologically active form of testosterone not bound to proteins.
Directly available for cellular uptake and biological effects.
Scientific Reference
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
