Testosterone Replacement Therapy (TRT) Decreases Ferritin

Nelson Vergel

Founder, ExcelMale.com
Testosterone replacement can cause a decrease in ferritin in men even without the presence or use of blood donations or therapeutic phlebotomies. A study gave men testosterone enanthate at a dose of 125 mg per week (it also used T enanthate with or without finasteride to see the effect of blocking 5 alpha reductase while on TRT). These are the ferritin values after 3 months. Ferritin was reduced at an average of 32% within 3 months of treatment initiation without altering iron, transferrin, or transferrin saturation.

decreased ferritin with TRT.jpg

Source: Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone


 
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Testosterone replacement can cause a decrease in ferritin in men even without the presence or use of blood donations or therapeutic phlebotomies. A study gave men testosterone enanthate at a dose of 125 mg per week (it also used T enanthate with or without finasteride to see the effect of blocking 5 alpha reductase while on TRT). These are the ferritin values after 3 months. Ferritin was reduced at an average of 32% within 3 months of treatment initiation without altering iron, transferrin, or transferrin saturation.

View attachment 14566
Source: Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone


Had to like this because I'm at 120 mg Test-E per week.
 

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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