Testosterone increasing IGF-1

Hypopit

New Member
Hello everyone. So I have a question on IGF-1, but first a little about myself. I'm deficient in T and GH and currently on HCG mono 11 weeks in. Things are going well, just trying to get E2 dialed in.

So about IGF-1.. How does Testosterone increase IGF-1? I've seen studies where administering T increases IGF and just wondering how it happens and if the pituitary gland plays a role in it. One study in particular (can't link it) a 300 MG Testosterone group (1345 ng/dl) after 16 weeks saw their IGF1 rise by 74 points (ng/ml). Can I expect the same increase in IGF-1 as seen in that study or will my weak GH deficient pituitary gland cause me to have a lower increase in IGF-1?

The 300MG group in that study had a 74 point increase in IGF-1 which is very nice. if I could get an increase like that then I don't think I'd bother getting on GH..

My baseline IGF-1 was 60 ng/ml range: 88-246. Currently it's at 72 ng/ml.

Testosterone currently at 1685 ng/dl range: 348 - 1197
 
Here is my experience!
I did HCG Mono for 6 weeks, then we tested, and the IGF was on the upper Range or even above. Without HRT - my hormones are on the bottom (T, ft, DHT, E2, Progesterone and and and..). But I don't know how my IGF would be without HRT. With Progesterone it is the same. With HCG it is very high, but without HRT it is low.
 
I know everyone is different, but when I tried HCG mono it sent my E2 into the 90's. Many posts about this issue on this board...mainly it's hard for an ai to control the intra-testicular aromatization caused by HCG use. Others are way more versed in this than me but monitor morning wood & nipple sensitivity closely.
 

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TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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