Testosterone: Improving Women's Brains

madman

Super Moderator

In this conversation, Dr. Kelly Casperson discusses a significant study on the effects of transdermal testosterone therapy on mood and cognitive symptoms in peri- and postmenopausal women. She emphasizes the importance of addressing hormonal changes and their impact on women's mental health, particularly during menopause. The study reveals that testosterone therapy can lead to improvements in mood and cognitive function, challenging the notion that there is insufficient data on testosterone's benefits for women. Dr. Casperson also critiques the study's limitations and calls for further research in this area, while engaging with her audience on related questions and concerns.




Takeaways

→Testosterone therapy can improve mood and cognitive symptoms in women.

→The study involved 510 women with persistent low libido and mood symptoms.

→Mood improvements were more significant than cognitive improvements.

→Testosterone does not drop off a cliff with menopause; it declines gradually.

→Hormonal changes during menopause can lead to increased risk of depression and cognitive impairment.

→Testosterone therapy may be a safer alternative to SSRIs for mood issues in perimenopausal women.

→The study highlights the need for more research on testosterone's effects in women.

→Libido is closely linked to mood; improving one can enhance the other.

→Transdermal testosterone is generally safe and easy to administer.

→Women should be informed about their options for hormone therapy.





Chapters


00:00 Introduction to Testosterone Therapy for Women
06:11 Understanding Hormonal Changes in Women
11:56 Study Methodology and Inclusion Criteria
18:12 Critiques and Limitations of the Study
23:53 Audience Interaction and Q&A
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

Beyond Testosterone Podcast

Online statistics

Members online
7
Guests online
227
Total visitors
234

Latest posts

Back
Top