Testosterone Crisis: Why Levels Have Dropped 50% in 40 Years — Hidden Hormone Disruptors, TRT Breakthroughs, & The Truth for Men and Women’s Health

madman

Super Moderator
[42:00] Fertility, LH/FSH suppression, and pilot study data


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Testosterone levels have dropped by nearly 50% over the past 40 years, creating ripple effects in metabolism, mood, fertility, and longevity. In this episode, you’ll learn why hormones are declining across both men and women, the hidden role of endocrine disruptors, and how lifestyle, TRT, and new oral formulations are changing the conversation about hormone health. Discover the metabolic, cardiovascular, and brain benefits of testosterone and what myths need to be debunked once and for all.




KEY TOPICS


* Testosterone decline and its link to obesity, diabetes, and cardiovascular disease

* The impact of endocrine disruptors, sleep loss, and lifestyle on hormone levels

* Symptoms of testosterone deficiency in men and women

* TRT delivery methods including injectables, gels, pellets, and new oral formulations

* Testosterone’s role in metabolism, brain health, and longevity





TIMESTAMPS

[00:00] Testosterone decline over the last 40 years and why it matters
[03:27] Causes of low testosterone: obesity, endocrine disruptors, poor sleep
[06:09] Symptoms and metabolic consequences of testosterone deficiency
[09:45] Can lifestyle changes restore testosterone without TRT?
[15:09] How low testosterone shows up in women and its health impacts
[17:01] History of testosterone therapy, stigma, and FDA regulation
[22:16] Current TRT options: injectables, pellets, gels, and compounded creams
[33:06] Innovation in oral testosterone and SHBG reduction
[42:00] Fertility, LH/FSH suppression, and pilot study data
[55:33] Testosterone’s connection to longevity, chronic disease, and healthspan
[58:23] Myths about cardiovascular risk, prostate cancer, and testosterone use
[01:00:51] Hormones as a foundation of health and how to get tested
 
 
 

hCG Mixing Calculator

HCG Mixing Protocol Calculator

TRT Hormone Predictor Widget

TRT Hormone Predictor

Predict estradiol, DHT, and free testosterone levels based on total testosterone

⚠️ Medical Disclaimer

This tool provides predictions based on statistical models and should NOT replace professional medical advice. Always consult with your healthcare provider before making any changes to your TRT protocol.

ℹ️ Input Parameters

Normal range: 300-1000 ng/dL

Predicted Hormone Levels

Enter your total testosterone value to see predictions

Results will appear here after calculation

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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