Testosterone and Cognitive Ability in Older Men

Jinzang

Member
Recent news articles have claimed that there is no good evidence of cognitive benefits from testosterone therapy. However, a recent meta-analysis found "strong evidence" of benefit. The study is described in a news article in Medical Express:

Taking testosterone supplements can boost men's brain health into old age, a new research review has found. Researchers from Edith Cowan University (ECU) analyzed the results of previous randomized control trials that examined if taking testosterone supplements improved cognitive function in older men.

Co-author of the study Associate Professor Hamid Sohrabi, from ECU's Centre of Excellence for Alzheimer's Disease Research and Care, and Murdoch University School of Psychology and Exercise Science said his analysis of previous clinical trials found strong evidence that testosterone supplementation improves decision-making, judgment and problem-solving ability in older men.

"As we age our brains gradually shrink, leading to a decline in memory, problem-solving and other cognitive functions," Professor Sohrabi said.

"This evidence shows that testosterone supplementation may help men stay mentally sharp into old age."

The researchers analyzed the results of 14 randomized controlled trials, including one recently published in the American Journal of Geriatric Psychiatry.
 
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Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038

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