We also know hematocrit can be increased by testosterone preparations. It depends on the preparation, and we think that there is data that shows that the threshold of 52-54% should not be surpassed, and men should be controlled for the hematocrit especially in the first year of treatment every 3 months
Hematocrit & Thromboembolic Risk
* TTh increase Hematocrit -clinically relevant at >52-54%
* Recommended: Control Hematocrit every 3 months in the 1st year
In September 2024, Androlabs held a Scientific Advisory Committee (SAC) meeting in London, bringing together 17 of Europe's most prominent key opinion leaders in men's health and endocrinology to the Royal Society of Medicine. The SAC meeting provided a dynamic forum for open discussion and knowledge sharing, with a focus on testosterone therapy and its effects on men's health.
KEY DISCUSSIONS ON MEN’S HEALTH AND TESTOSTERONE THERAPY
The meeting included in-depth discussions about key topics such as testosterone's cardiovascular safety, managing haematocrit responses to therapy, and understanding the efficacy of testosterone gels. Attendees agreed on several key points, including improved testosterone management education for healthcare providers. This discussion highlighted the importance of personalised care in testosterone therapy, as well as improving patient compliance during the first few months of treatment.
While substantial progress has been made in understanding the CV safety of TTh, key areas for future research remain to further refine its application and optimize patient outcomes.
1. Long-term CV outcomes: The TRAVERSE trial and similar studies have reassured us of TTh’s short-to-medium-term CV safety, yet long-term effects, especially across diverse populations, require further investigation. Extended follow-up studies are needed to assess the potential for long-term CV safety in men undergoing decades-long TTh.
* our meta-analysis stands as the most up to date analysis restricted to RCTs directed to men aged 40 or older.
* The main fndings were as follows: (1) there were no significant diferences between groups in all-cause mortality, cardiovascular mortality, MI, and stroke; (2) TRT signifcantly increased the incidence of cardiac arrhythmias; (3) TRT was associated with decreased levels of HDL-c; and (4) there was a marginal increase in SBP levels in the TRT group.
Long‑Term Cardiovascular Safety of Testosterone‑Replacement Therapy in Middle‑Aged and Older...
Predict estradiol, DHT, and free testosterone levels based on total testosterone
⚠️ Medical Disclaimer
This tool provides predictions based on statistical models and should NOT replace professional medical advice.
Always consult with your healthcare provider before making any changes to your TRT protocol.
ℹ️ Input Parameters
Normal range: 300-1000 ng/dL
Predicted Hormone Levels
Enter your total testosterone value to see predictions
Results will appear here after calculation
Understanding Your Hormones
Estradiol (E2)
A form of estrogen produced from testosterone. Important for bone health, mood, and libido.
Too high can cause side effects; too low can affect well-being.
DHT
Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth,
prostate health, and masculinization effects.
Free Testosterone
The biologically active form of testosterone not bound to proteins.
Directly available for cellular uptake and biological effects.
Scientific Reference
Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.
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