Tesamorelin + Tesofensine

[mrRiKo]

Hey guys,

I suffer much on fatliver and I need urgently to loos this.
So I tought to make this with a capsule per day tesofensin and injection a mix of tesamorelin & ipamorelin.

What u guys think about this mix and what u would suggest me for dosage for the injection.

I wonder if I can use injectionpens like for insulin?
Thanks a lot for all ur help

 

[BadassBlues]

Tesamorelin has shown efficacy in treating fatty liver disease. It is very similar to Ipamorelin and the two are often combined. Tesamorelin in it's brand name form (Egrifta) is used to treat lipodystrophy (excess body fat) in HIV patients. Ipamorelin is also effective in weight loss.

Tesofensine is a serotonin and dopamine reuptake inhibitor that has shown to be effective for weight loss.

The combination of these is often used for weight loss with very good results. Is that your goal? Have you been diagnosed with fatty liver disease?

Peptides must be reconstituted using bacteriostatic water. Yes, they are injected using an insulin syringe. If you are new to this, you need to do some research to learn how to mix the peptides and to properly administer an injection. The dosage will be determined on whether you use a blend or if you decide to use just one of the peptides.

Drug reverses signs of liver disease in people living with HIV

Tesamorelin prevented progression to liver fibrosis in NIH study.

www.nih.gov

Drug reverses signs of liver disease in people living with HIV​

Tesamorelin prevented progression to liver fibrosis in NIH study.

[IMG alt="A microscopic image of liver tissue"]https://www.nih.gov/sites/default/f...jpg?itok=AgNZ3n52&timestamp=1570804935[/IMG]A microscopic image of liver tissue affected by non-alcoholic fatty liver disease (NAFLD). The large and small white spots are excess fat droplets filling liver cells (hepatocytes). Dr. David Kleiner, NCI
Researchers at the National Institutes of Health and their colleagues at Massachusetts General Hospital (MGH) in Boston report that the injectable hormone tesamorelin reduces liver fat and prevents liver fibrosis (scarring) in people living with HIV. The study was conducted by the National Institute of Allergy and Infectious Diseases (NIAID) and the National Cancer Institute, both parts of NIH. The findings were published online today in The Lancet HIV

“Many people living with HIV have overcome significant obstacles to live longer, healthier lives, though many still experience liver disease,” said NIAID Director Anthony S. Fauci, M.D. “It is encouraging that tesamorelin, a drug already approved to treat other complications of HIV, may be effective in addressing non-alcoholic fatty liver disease.”

Non-alcoholic fatty liver disease, or NAFLD, frequently occurs alongside HIV, affecting as many as 25% of people living with HIV in the developed world. However, no effective treatments currently exist to treat the condition, which is a risk factor for progressive liver disease and liver cancer. Investigators led by Colleen M. Hadigan, M.D., senior research physician in NIAID’s Laboratory of Immunoregulation, and Steven K. Grinspoon, M.D., Chief of the Metabolism Unit at MGH, tested whether tesamorelin could decrease liver fat in men and women living with both HIV and NAFLD. Among the participants enrolled, 43% had at least mild fibrosis, and 33% met the diagnostic criteria for a more severe subset of NAFLD called nonalcoholic steatohepatitis (NASH). Thirty-one participants were randomized to receive daily 2-mg injections of tesamorelin, and 30 were randomized to receive identical-looking injections containing a placebo. Researchers provided nutritional counseling to all participants, as well as training in self-administering the daily injections. Researchers then compared measures of liver health in both groups at baseline and 12 months.

After one year, participants receiving tesamorelin had better liver health than those receiving placebo, as defined by reduction in hepatic fat fraction (HFF)—the ratio of fat to other tissue in the liver. The healthy range for HFF is less than 5%. Thirty-five percent of study participants receiving tesamorelin achieved a normal HFF, while only 4% of those on placebo reached that range with nutritional advice alone. Overall, tesamorelin was well-tolerated and reduced participants’ HFF by an absolute difference of 4.1% (corresponding to a 37% relative reduction from the beginning of the study). While nine participants receiving placebo experienced onset or worsening of fibrosis, only two participants in the tesamorelin group experienced the same. Additionally, levels of several blood markers associated with inflammation and liver damage — including the enzyme alanine aminotransferase (ALT) — decreased more among those taking tesamorelin compared to those on a placebo, particularly among those with increased levels at the beginning of the study.

Given these positive results, investigators suggest expanding the indication for tesamorelin to include people living with HIV who have been diagnosed with NAFLD. They also recommend additional research to determine if tesamorelin could contribute to long-term protection against serious liver disease in people without HIV.

“Our hope is that this intervention may help people living with HIV, as well as benefit HIV-negative people with liver abnormalities,” said Dr. Hadigan. “Further research may inform us of the potential long-term benefits of this approach and develop formulations that can benefit everyone with liver disease, regardless of HIV status.”

Egrifta (tesamorelin) was approved in 2010 by the U.S. Food and Drug Administration to reduce excess abdominal fat in HIV patients with lipodystrophy — a complication characterized by an abnormal distribution of body fat initially associated with older classes of HIV medications. The most commonly reported side effects in previous clinical trials evaluating Egrifta included joint pain (arthralgia), skin redness and rash at the injection site (erythema and pruritis), stomach pain, swelling, and muscle pain (myalgia). Worsening blood sugar control occurred more often in trial participants treated with Egrifta than with placebo.

“Because tesamorelin proved effective in treating abnormal fat build-up in the abdomens of people in the context of HIV and related medication use, we hypothesized that the drug might also reduce fat that accrues in the liver and causes damage in a similar population,” said Dr. Grinspoon.

While liver disease is often associated with heavy alcohol use, NAFLD occurs when excess fat builds up in the liver without alcohol as a contributing factor. This condition may progress to liver damage, cirrhosis or cancer that could be life-threatening and necessitate liver transplantation.

Previous studies have found that vitamin E supplements, weight loss and other lifestyle changes can improve outcomes among HIV-negative people with NASH. However, treatment options for NASH and NAFLD are often not tested in people with HIV and none are available for this group. Obesity and type 2 diabetes raise the risk of developing NAFLD regardless of HIV status, and people with HIV are at increased risk of NAFLD because some HIV medications and HIV itself are associated with gaining abdominal fat and may contribute to liver fat build-up.

 

[mrRiKo]

Thanks a lot for ur very detailed answer and explanation. I very appreciate this.
Yes im overweight and have diagnosed fat liver. I simply can't loos it, so I'm I'm in a circle.

My idea was to combine all 3 together. So
Take one capsule tesofensin and combine tesamorelin with ipamorelin.
Can u explain me the bacteriostatic mixing ?
Is there a way to calculate the dosage of water + tesamorelin +ipamorelin?

U know, my idea was to buy a injectionpan, that are used for diabetics. So I just need to replace the needle. But those pens use a other kind if bottle, and I didnt find a universal bottle which I can refill

 

[BadassBlues]

As for the syringes, I have found these to be the best:

Amazon.com

Tesamorelin is an FDA approved drug. The daily recommended dosage is 2mg, 5 days on, 2 days off. Best to inject at night before bed. At 2 mg per dose, this is an expensive peptide as most products come in 5mg vials.

Ipamorelin is not FDA approved, so the dosage recommendations are from researchers. Most research shows a dose of 200-300mcg. Some researchers have used higher doses, but not for the purpose you are detailing.

Tesofensine should come with a recommended dose on the bottle.

A peptide calculator is here:

Peptide Calculator (Beta) ⋆ Peptide Reconstitution Calculator (Beta)

You will need bacteriostatic water to reconstitute the peptides:

Amazon.com

How to Reconstitute Peptides | A Comprehensive Review

Curious about how to reconstitute peptides? Inside this guide, our research team breaks down everything to know about peptide handling, reconstitution, and storage.

www.peptides.org

 

[Guided_by_Voices]

Supplementing with Choline/Inositol and micro-dosing metformin (250mg before meals) are two other things to consider. Intermittent or longer fasting may help too.

 

[BadassBlues]

Not to assume anything, but these alone will not fix a bad diet and lifestyle. a well thought out diet and exercise regimen are required. Some other supplements to consider for the liver are Silymarin and Tudca. I take these and have had excellent success in keeping liver numbers in good range.

 

[mrRiKo]

Thanks a lot again for ur big help.
Those are amazing Information and makes it much easier.
I did order this stuff at swisschems, bit somehow its since 4 days in Brüssel.
However, I saw a proposal of 0,5 mg tesa and 0,5-1,5 ipamorelin.
Is this also ok? Or to less? I did order a 2mg vial. This is just enough for one day?

how fast those peptides starts to work?

As for the syringes, I have found these to be the best:

Amazon.com

Tesamorelin is an FDA approved drug. The daily recommended dosage is 2mg, 5 days on, 2 days off. Best to inject at night before bed. At 2 mg per dose, this is an expensive peptide as most products come in 5mg vials.

Ipamorelin is not FDA approved, so the dosage recommendations are from researchers. Most research shows a dose of 200-300mcg. Some researchers have used higher doses, but not for the purpose you are detailing.

Tesofensine should come with a recommended dose on the bottle.

A peptide calculator is here:

Peptide Calculator (Beta) ⋆ Peptide Reconstitution Calculator (Beta)

You will need bacteriostatic water to reconstitute the peptides:

Amazon.com

How to Reconstitute Peptides | A Comprehensive Review

Curious about how to reconstitute peptides? Inside this guide, our research team breaks down everything to know about peptide handling, reconstitution, and storage.

www.peptides.org

 

[mrRiKo]

Supplementing with Choline/Inositol and micro-dosing metformin (250mg before meals) are two other things to consider. Intermittent or longer fasting may help too.

Thank u, I will have a look at it

 

[BadassBlues]

Thanks a lot again for ur big help.
Those are amazing Information and makes it much easier.
I did order this stuff at swisschems, bit somehow its since 4 days in Brüssel.
However, I saw a proposal of 0,5 mg tesa and 0,5-1,5 ipamorelin.
Is this also ok? Or to less? I did order a 2mg vial. This is just enough for one day?

how fast those peptides starts to work?

If you are following a caloric deficit diet and doing at least 5 hours a week of moderately intensive exercise including cardio and weight training, you can expect to see results in 8 weeks.

Diet and exercise are key to success.

The only variation in dosage for Tesamorelin I have seen is 1mg. The dosage prescribed for fat loss is 2mg per day, 5 days on-2 days off for an 8 week cycle.

 

[BadassBlues]

Here is a link to a new book out by Jay Campbell which emphasizes all of the peptides you mentioned, along with others. Also, diet and exercise tips designed for weight loss.

Amazon.com

As a disclaimer, Jay Campbell is a knowledgeable source for peptides, diet and exercise, also for sourcing good quality peptides via Limitless Peptides. However, he also has a financial stake in the game and is heavily biased. If you give your email to his website, expect your inbox to be blown up with ads and sales pitches... along with his somewhat arrogant and misdirected points of view on a range of topics. I do have respect for his knowledge of peptides and the fact that he is putting himself out there, but he is a bit of an opinionated and abrasive person who believes himself to be just a bit more than he truly is.

I do recommend the book however.

 

[jnde207]

Hey guys,

I suffer much on fatliver and I need urgently to loos this.
So I tought to make this with a capsule per day tesofensin and injection a mix of tesamorelin & ipamorelin.

What u guys think about this mix and what u would suggest me for dosage for the injection.

I wonder if I can use injectionpens like for insulin?
Thanks a lot for all ur help

I just got diagnosed with a "fatty" liver, but I was on superdrol 10mg/day for 2 weeks during they episode, so I stopped and cleaned up my diet with MORE water. I went back to get blood tests 4 weeks later and everything was perfectly normal again.
The best thing for a fatty liver is a clean diet and lots of water, now if you've done that and haven't seen any results then I would consider medications but it would be better for you if you could clean it up without medications.
Good luck and I hope everything goes well for you.
P. S. - I've seen 3 different Drs in that 4 week period and all of them have told me that pretty much everyone has a "fatty" liver now days because of what we eat.